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- W1574408743 abstract "Recent research suggest that B and plasma cells may play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this study was to subcharacterize the B cell response in the sinus mucosa of control and CRS patients.Representative tissue samples and peripheral blood samples were obtained from controls, CRS without nasal polyps (CRSsNP) and CRSwNP. Using single-cell suspension flow cytometry these samples were analyzed for overall and stage-specific B and plasma cell percentages.Both atopic and nonatopic CRSwNP patients showed an increase in local numbers of naive, active, and memory B cells compared to controls. CRSsNP patients only showed local elevations of naive B cells. Plasma cells were only significantly elevated in the sinus tissue of atopic CRSwNP patients. These local tissue increases did not correlate with increased numbers of circulating B cells.This study provides further evidence of an important role of B cells in CRSwNP patients. The local increase appears to be independent of a systemic response." @default.
- W1574408743 created "2016-06-24" @default.
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- W1574408743 date "2013-05-02" @default.
- W1574408743 modified "2023-10-18" @default.
- W1574408743 title "Characterization of B-cell subpopulations in patients with chronic rhinosinusitis" @default.
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- W1574408743 doi "https://doi.org/10.1002/alr.21173" @default.
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