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- W1574476878 abstract "Tissue factor (TF) has now well recognized roles as a signaling receptor involved in the regulation of angiogenesis, tumor growth, metastasis and inflammation. TF initiates coagulation, leading to thrombin signaling through G protein coupled, protease activated receptors (PAR) 1, 3, and 4.1 However, the signaling activities of the TF-VIIa binary and the TF-VIIa-Xa ternary complex may occur prior to or even independently of generalized coagulation activation that lead to fibrin generation, platelet activation and thrombus formation.2 The TF-VIIa complex activates PAR2 and the product of initiation of coagulation, Xa, while still assembled in the transient ternary TF-VIIa-Xa complex, signals through PAR1 or PAR2." @default.
- W1574476878 created "2016-06-24" @default.
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- W1574476878 date "2009-06-03" @default.
- W1574476878 modified "2023-09-23" @default.
- W1574476878 title "Tissue factor-PAR2 signaling crosstalk in cancer and angiogenesis" @default.
- W1574476878 doi "https://doi.org/10.4081/hmr.v1i9.314" @default.
- W1574476878 hasPublicationYear "2009" @default.
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