Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574503486> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1574503486 endingPage "8" @default.
- W1574503486 startingPage "1" @default.
- W1574503486 abstract "Human genomic DNA is continuously attacked by oxygen radicals originated from cellular metabolic processes and numerous environmental carcinogens. 2-deoxyribonolactone (dL) is a major type of oxidized abasic (AP) lesion implicated in DNA strand scission, mutagenesis, and formation of covalent DNA-protein crosslink (DPC) with DNA polymerase (Pol) β. We show here that human DNA polymerase (Pol) ι and mitochondrial Polγ give rise to stable DNA-protein crosslink (DPC) formation that is specifically mediated by dL lesion. Polι mediates DPC formation at the incised dL residue by its 5'-deoxyribose-5-phosphate (dRP) lyase activity, while Polγ crosslinks with dL thorough its intrinsic dRP lyase and AP lyase activities. Reactivity in forming dL-mediated DPC was significantly higher with Polγ than with Polι. DPC formation by Polγ, however, can be reduced by an accessory factor of Polγ holoenzyme that may attenuate deleterious effects of crosslink adducts on mitochondrial DNA. Comparative kinetic analysis of DPC formation showed that the rate of DPC formation with either Polι or Polγ was lower than that with Polβ. These results revealed that the activity of catalytic lyase in DNA polymerases determine the efficiency of DPC formation with dL damages. Irreversible crosslink formation of such DNA polymerases by dL lesions may result in a prolonged strand scission and a suicide of DNA repair proteins, both of which could pose a threat to the genetic and structural integrity of DNA." @default.
- W1574503486 created "2016-06-24" @default.
- W1574503486 creator A5042009416 @default.
- W1574503486 creator A5060338137 @default.
- W1574503486 creator A5065193815 @default.
- W1574503486 creator A5073631855 @default.
- W1574503486 date "2009-03-01" @default.
- W1574503486 modified "2023-09-24" @default.
- W1574503486 title "Formation of DNA-Protein Crosslink at Oxidized Abasic Site Mediated by Human DNA Polymerase Iota and Mitochondrial DNA Polymerase Gamma" @default.
- W1574503486 cites W2141445416 @default.
- W1574503486 cites W2206839028 @default.
- W1574503486 hasPublicationYear "2009" @default.
- W1574503486 type Work @default.
- W1574503486 sameAs 1574503486 @default.
- W1574503486 citedByCount "0" @default.
- W1574503486 crossrefType "journal-article" @default.
- W1574503486 hasAuthorship W1574503486A5042009416 @default.
- W1574503486 hasAuthorship W1574503486A5060338137 @default.
- W1574503486 hasAuthorship W1574503486A5065193815 @default.
- W1574503486 hasAuthorship W1574503486A5073631855 @default.
- W1574503486 hasConcept C104317684 @default.
- W1574503486 hasConcept C131140672 @default.
- W1574503486 hasConcept C134935766 @default.
- W1574503486 hasConcept C143425029 @default.
- W1574503486 hasConcept C150777479 @default.
- W1574503486 hasConcept C153911025 @default.
- W1574503486 hasConcept C156719811 @default.
- W1574503486 hasConcept C185592680 @default.
- W1574503486 hasConcept C192396546 @default.
- W1574503486 hasConcept C2756471 @default.
- W1574503486 hasConcept C31254050 @default.
- W1574503486 hasConcept C49105822 @default.
- W1574503486 hasConcept C552990157 @default.
- W1574503486 hasConcept C55493867 @default.
- W1574503486 hasConcept C76535049 @default.
- W1574503486 hasConcept C82381507 @default.
- W1574503486 hasConcept C86803240 @default.
- W1574503486 hasConcept C88354546 @default.
- W1574503486 hasConceptScore W1574503486C104317684 @default.
- W1574503486 hasConceptScore W1574503486C131140672 @default.
- W1574503486 hasConceptScore W1574503486C134935766 @default.
- W1574503486 hasConceptScore W1574503486C143425029 @default.
- W1574503486 hasConceptScore W1574503486C150777479 @default.
- W1574503486 hasConceptScore W1574503486C153911025 @default.
- W1574503486 hasConceptScore W1574503486C156719811 @default.
- W1574503486 hasConceptScore W1574503486C185592680 @default.
- W1574503486 hasConceptScore W1574503486C192396546 @default.
- W1574503486 hasConceptScore W1574503486C2756471 @default.
- W1574503486 hasConceptScore W1574503486C31254050 @default.
- W1574503486 hasConceptScore W1574503486C49105822 @default.
- W1574503486 hasConceptScore W1574503486C552990157 @default.
- W1574503486 hasConceptScore W1574503486C55493867 @default.
- W1574503486 hasConceptScore W1574503486C76535049 @default.
- W1574503486 hasConceptScore W1574503486C82381507 @default.
- W1574503486 hasConceptScore W1574503486C86803240 @default.
- W1574503486 hasConceptScore W1574503486C88354546 @default.
- W1574503486 hasIssue "1" @default.
- W1574503486 hasLocation W15745034861 @default.
- W1574503486 hasOpenAccess W1574503486 @default.
- W1574503486 hasPrimaryLocation W15745034861 @default.
- W1574503486 hasRelatedWork W1760601206 @default.
- W1574503486 hasRelatedWork W1979677275 @default.
- W1574503486 hasRelatedWork W1992809685 @default.
- W1574503486 hasRelatedWork W2025661917 @default.
- W1574503486 hasRelatedWork W2045255868 @default.
- W1574503486 hasRelatedWork W2047455537 @default.
- W1574503486 hasRelatedWork W2062281408 @default.
- W1574503486 hasRelatedWork W2064477710 @default.
- W1574503486 hasRelatedWork W2068649233 @default.
- W1574503486 hasRelatedWork W2136437568 @default.
- W1574503486 hasRelatedWork W2151444462 @default.
- W1574503486 hasRelatedWork W2188342745 @default.
- W1574503486 hasRelatedWork W2197746163 @default.
- W1574503486 hasRelatedWork W2565135425 @default.
- W1574503486 hasRelatedWork W2765587297 @default.
- W1574503486 hasRelatedWork W2836160132 @default.
- W1574503486 hasRelatedWork W2886842423 @default.
- W1574503486 hasRelatedWork W2919123393 @default.
- W1574503486 hasRelatedWork W2967573610 @default.
- W1574503486 hasRelatedWork W3165568401 @default.
- W1574503486 hasVolume "15" @default.
- W1574503486 isParatext "false" @default.
- W1574503486 isRetracted "false" @default.
- W1574503486 magId "1574503486" @default.
- W1574503486 workType "article" @default.