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- W1574516418 abstract "Abstract The plasma membrane is compartmentalized into microdomains and the association/dissociation of receptors and signaling molecules with/from these membrane domains is a major principle for regulation of signal transduction. By following the reorganization of microdomains on living cells and performing biochemical studies, we show that Ab targeting of the T cell activation-associated Ag CD147 prevents TCR stimulation-dependent reorganization and clustering of microdomains. Triggering CD147 induces a displacement of the GPI-anchored coreceptors CD48 and CD59 from microdomains in human T lymphocytes. This perturbation of microdomains is accompanied by a selective inhibition of TCR-mediated T cell proliferation. The CD147-inhibited cells secret normal levels of IL-2 but acquire reduced amounts of the IL-2 receptor α-chain CD25. These results indicate that negative regulating signals can modulate microdomains and suggest a general mechanism for inhibition of receptor signaling." @default.
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- W1574516418 date "2003-08-15" @default.
- W1574516418 modified "2023-10-16" @default.
- W1574516418 title "Selective Inhibition of T Cell Activation Via CD147 Through Novel Modulation of Lipid Rafts" @default.
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- W1574516418 doi "https://doi.org/10.4049/jimmunol.171.4.1707" @default.
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