Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574604144> ?p ?o ?g. }
- W1574604144 endingPage "e0135365" @default.
- W1574604144 startingPage "e0135365" @default.
- W1574604144 abstract "Disease modifying treatments for Alzheimer’s disease (AD) constitute a major goal in medicine. Current trends suggest that biomarkers reflective of AD neuropathology and modifiable by treatment would provide supportive evidence for disease modification. Nevertheless, a lack of quantitative tools to assess disease modifying treatment effects remains a major hurdle. Cerebrospinal fluid (CSF) biochemical markers such as total tau, p-tau and Ab42 are well established markers of AD; however, global quantitative biochemical changes in CSF in AD disease progression remain largely uncharacterized. Here we applied a high resolution open discovery platform, dMS, to profile a cross-sectional cohort of lumbar CSF from post-mortem diagnosed AD patients versus those from non-AD/non-demented (control) patients. Multiple markers were identified to be statistically significant in the cohort tested. We selected two markers SME-1 (p<0.0001) and SME-2 (p = 0.0004) for evaluation in a second independent longitudinal cohort of human CSF from post-mortem diagnosed AD patients and age-matched and case-matched control patients. In cohort-2, SME-1, identified as neuronal secretory protein VGF, and SME-2, identified as neuronal pentraxin receptor-1 (NPTXR), in AD were 21% (p = 0.039) and 17% (p = 0.026) lower, at baseline, respectively, than in controls. Linear mixed model analysis in the longitudinal cohort estimate a decrease in the levels of VGF and NPTXR at the rate of 10.9% and 6.9% per year in the AD patients, whereas both markers increased in controls. Because these markers are detected by mass spectrometry without the need for antibody reagents, targeted MS based assays provide a clear translation path for evaluating selected AD disease-progression markers with high analytical precision in the clinic." @default.
- W1574604144 created "2016-06-24" @default.
- W1574604144 creator A5000250967 @default.
- W1574604144 creator A5000956002 @default.
- W1574604144 creator A5004210612 @default.
- W1574604144 creator A5007981280 @default.
- W1574604144 creator A5008113112 @default.
- W1574604144 creator A5011047858 @default.
- W1574604144 creator A5012418100 @default.
- W1574604144 creator A5012441499 @default.
- W1574604144 creator A5018772991 @default.
- W1574604144 creator A5021432816 @default.
- W1574604144 creator A5022513797 @default.
- W1574604144 creator A5025996002 @default.
- W1574604144 creator A5030330229 @default.
- W1574604144 creator A5036198594 @default.
- W1574604144 creator A5037006397 @default.
- W1574604144 creator A5039973225 @default.
- W1574604144 creator A5040749819 @default.
- W1574604144 creator A5040929848 @default.
- W1574604144 creator A5044512570 @default.
- W1574604144 creator A5045350974 @default.
- W1574604144 creator A5047780776 @default.
- W1574604144 creator A5056573353 @default.
- W1574604144 creator A5066657162 @default.
- W1574604144 creator A5069167318 @default.
- W1574604144 creator A5070087445 @default.
- W1574604144 creator A5073618200 @default.
- W1574604144 creator A5075866956 @default.
- W1574604144 creator A5076915974 @default.
- W1574604144 creator A5077942876 @default.
- W1574604144 creator A5078562981 @default.
- W1574604144 creator A5079156289 @default.
- W1574604144 creator A5081444720 @default.
- W1574604144 date "2015-08-13" @default.
- W1574604144 modified "2023-09-27" @default.
- W1574604144 title "High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer’s Disease in Human Cerebrospinal Fluid" @default.
- W1574604144 cites W111028273 @default.
- W1574604144 cites W1523782066 @default.
- W1574604144 cites W1575982426 @default.
- W1574604144 cites W1594504409 @default.
- W1574604144 cites W1965208860 @default.
- W1574604144 cites W1970673364 @default.
- W1574604144 cites W1972025839 @default.
- W1574604144 cites W1975756947 @default.
- W1574604144 cites W1981322456 @default.
- W1574604144 cites W1988195734 @default.
- W1574604144 cites W1996947415 @default.
- W1574604144 cites W1997504014 @default.
- W1574604144 cites W2001179326 @default.
- W1574604144 cites W2008301592 @default.
- W1574604144 cites W2015556811 @default.
- W1574604144 cites W2024288744 @default.
- W1574604144 cites W2025339182 @default.
- W1574604144 cites W2027659387 @default.
- W1574604144 cites W2028590992 @default.
- W1574604144 cites W2033354781 @default.
- W1574604144 cites W2034016536 @default.
- W1574604144 cites W2034286717 @default.
- W1574604144 cites W2037839118 @default.
- W1574604144 cites W2041032262 @default.
- W1574604144 cites W2041486735 @default.
- W1574604144 cites W2046807462 @default.
- W1574604144 cites W2050324677 @default.
- W1574604144 cites W2051952557 @default.
- W1574604144 cites W2052226492 @default.
- W1574604144 cites W2054806352 @default.
- W1574604144 cites W2058471763 @default.
- W1574604144 cites W2059749939 @default.
- W1574604144 cites W2061866146 @default.
- W1574604144 cites W2062410112 @default.
- W1574604144 cites W2068481474 @default.
- W1574604144 cites W2068857365 @default.
- W1574604144 cites W2070437724 @default.
- W1574604144 cites W2075193321 @default.
- W1574604144 cites W2082429191 @default.
- W1574604144 cites W2089742422 @default.
- W1574604144 cites W2091002427 @default.
- W1574604144 cites W2092657822 @default.
- W1574604144 cites W2099614709 @default.
- W1574604144 cites W2103825172 @default.
- W1574604144 cites W2105743998 @default.
- W1574604144 cites W2110225477 @default.
- W1574604144 cites W2112078820 @default.
- W1574604144 cites W2113577365 @default.
- W1574604144 cites W2114330749 @default.
- W1574604144 cites W2123886946 @default.
- W1574604144 cites W2125993125 @default.
- W1574604144 cites W2131872164 @default.
- W1574604144 cites W2140771485 @default.
- W1574604144 cites W2142688398 @default.
- W1574604144 cites W2152913498 @default.
- W1574604144 cites W2153569004 @default.
- W1574604144 cites W2155696186 @default.
- W1574604144 cites W2156220037 @default.
- W1574604144 cites W2162193325 @default.
- W1574604144 cites W2168334242 @default.
- W1574604144 cites W2325429075 @default.