Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574643997> ?p ?o ?g. }
- W1574643997 endingPage "14904" @default.
- W1574643997 startingPage "14899" @default.
- W1574643997 abstract "In this study, we addressed the question of whether carcinogens affected the expression of interleukin-1 alpha (IL1 alpha), interleukin-1 beta (IL1 beta), and interleukin-6 (IL6) genes and the production of the relative proteins. Primary cultures of human monocytes were exposed to the alkylating agents mitomycin C (Mit C), methylmethane sulfonate (MMS), and ethylmethane sulfonate (EMS) and tested for the production of IL1 alpha, IL1 beta, and IL6 proteins, as well as for the expression of IL1 alpha, IL1 beta, and IL6 transcripts. The production of IL1 beta and IL6 was significantly augmented by all the three chemicals after 24-48 h of treatment. IL1 alpha was also increased by Mit C and MMS. By Northern blotting analysis, the increased expression of IL1 alpha, IL1 beta, and IL6 genes was shown to occur at 30 min of Mit C and MMS treatment and to decline after 8 h. Similarly, EMS up-regulated the expression of IL1 beta and IL6 genes. The mutagen-mediated increase in interleukin transcripts did not require de novo protein synthesis, and it was due to the enhanced half-life of IL1 alpha, IL1 beta, and IL6 mRNAs rather than to the increased rate of gene transcription. These results suggest that carcinogens, in addition to causing DNA mutations and rearrangements, may also affect cell growth and differentiation by enhancing the expression of cytokine genes." @default.
- W1574643997 created "2016-06-24" @default.
- W1574643997 creator A5001102777 @default.
- W1574643997 creator A5029925224 @default.
- W1574643997 creator A5032613353 @default.
- W1574643997 creator A5040492155 @default.
- W1574643997 creator A5077903787 @default.
- W1574643997 date "1994-05-01" @default.
- W1574643997 modified "2023-10-10" @default.
- W1574643997 title "DNA damaging agents increase the stability of interleukin-1 alpha, interleukin-1 beta, and interleukin-6 transcripts and the production of the relative proteins." @default.
- W1574643997 cites W1528281043 @default.
- W1574643997 cites W1535142102 @default.
- W1574643997 cites W1568529372 @default.
- W1574643997 cites W1574330564 @default.
- W1574643997 cites W1577743059 @default.
- W1574643997 cites W1963550266 @default.
- W1574643997 cites W1971421846 @default.
- W1574643997 cites W1972310182 @default.
- W1574643997 cites W1974357188 @default.
- W1574643997 cites W1993210315 @default.
- W1574643997 cites W1993438256 @default.
- W1574643997 cites W1993713336 @default.
- W1574643997 cites W2000943484 @default.
- W1574643997 cites W2002076761 @default.
- W1574643997 cites W2003962192 @default.
- W1574643997 cites W2007000374 @default.
- W1574643997 cites W2014464617 @default.
- W1574643997 cites W2031553804 @default.
- W1574643997 cites W2034432392 @default.
- W1574643997 cites W2036452124 @default.
- W1574643997 cites W2040020188 @default.
- W1574643997 cites W2045854456 @default.
- W1574643997 cites W2051819610 @default.
- W1574643997 cites W2056086021 @default.
- W1574643997 cites W2057093252 @default.
- W1574643997 cites W2058455617 @default.
- W1574643997 cites W2058554371 @default.
- W1574643997 cites W2068961038 @default.
- W1574643997 cites W2080532845 @default.
- W1574643997 cites W2085451664 @default.
- W1574643997 cites W2086380033 @default.
- W1574643997 cites W2089778507 @default.
- W1574643997 cites W2094664478 @default.
- W1574643997 cites W2103449496 @default.
- W1574643997 cites W2127862787 @default.
- W1574643997 cites W2132000251 @default.
- W1574643997 cites W2139391306 @default.
- W1574643997 cites W2141001643 @default.
- W1574643997 cites W2168415166 @default.
- W1574643997 cites W2421037982 @default.
- W1574643997 cites W321573562 @default.
- W1574643997 cites W4294216491 @default.
- W1574643997 cites W53148147 @default.
- W1574643997 cites W61176855 @default.
- W1574643997 doi "https://doi.org/10.1016/s0021-9258(17)36550-x" @default.
- W1574643997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8195120" @default.
- W1574643997 hasPublicationYear "1994" @default.
- W1574643997 type Work @default.
- W1574643997 sameAs 1574643997 @default.
- W1574643997 citedByCount "13" @default.
- W1574643997 countsByYear W15746439972013 @default.
- W1574643997 countsByYear W15746439972015 @default.
- W1574643997 countsByYear W15746439972016 @default.
- W1574643997 countsByYear W15746439972020 @default.
- W1574643997 countsByYear W15746439972021 @default.
- W1574643997 crossrefType "journal-article" @default.
- W1574643997 hasAuthorship W1574643997A5001102777 @default.
- W1574643997 hasAuthorship W1574643997A5029925224 @default.
- W1574643997 hasAuthorship W1574643997A5032613353 @default.
- W1574643997 hasAuthorship W1574643997A5040492155 @default.
- W1574643997 hasAuthorship W1574643997A5077903787 @default.
- W1574643997 hasBestOaLocation W15746439971 @default.
- W1574643997 hasConcept C159110408 @default.
- W1574643997 hasConcept C185592680 @default.
- W1574643997 hasConcept C199360897 @default.
- W1574643997 hasConcept C203014093 @default.
- W1574643997 hasConcept C2775944032 @default.
- W1574643997 hasConcept C2776174256 @default.
- W1574643997 hasConcept C2777371288 @default.
- W1574643997 hasConcept C2778690821 @default.
- W1574643997 hasConcept C41008148 @default.
- W1574643997 hasConcept C49453240 @default.
- W1574643997 hasConcept C64943373 @default.
- W1574643997 hasConcept C71924100 @default.
- W1574643997 hasConcept C74172505 @default.
- W1574643997 hasConcept C86803240 @default.
- W1574643997 hasConceptScore W1574643997C159110408 @default.
- W1574643997 hasConceptScore W1574643997C185592680 @default.
- W1574643997 hasConceptScore W1574643997C199360897 @default.
- W1574643997 hasConceptScore W1574643997C203014093 @default.
- W1574643997 hasConceptScore W1574643997C2775944032 @default.
- W1574643997 hasConceptScore W1574643997C2776174256 @default.
- W1574643997 hasConceptScore W1574643997C2777371288 @default.
- W1574643997 hasConceptScore W1574643997C2778690821 @default.
- W1574643997 hasConceptScore W1574643997C41008148 @default.
- W1574643997 hasConceptScore W1574643997C49453240 @default.
- W1574643997 hasConceptScore W1574643997C64943373 @default.
- W1574643997 hasConceptScore W1574643997C71924100 @default.