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- W157464434 abstract "The past two decades have been marked by a dramatic increase in the knowledge of the genetics of human disease. The field of interstitial lung disease (ILD) genetics has expanded as well. Much of the early understanding of ILD genetics came from rare Mendelian disorders that were associated with premature onset of disease. Other information came from single-gene multisystem disorders in which lung disease was variably present. More recently, the major advances in ILD genetics have come from focused analysis of familial pulmonary fibrosis. These rare families with multiple members affected by ILD have provided critical new insight into the possible mechanism of sporadic as well as inherited disease. Both linkage studies and large-scale, genome-wide association studies (GWAS) have identified genetic loci implicated in susceptibility to idiopathic pulmonary fibrosis (IPF). The next two decades will surely produce not only new risk alleles but also a more extensive understanding of genetics based on patient molecular phenotyping. In addition, epigenetics remains an area of potential discovery." @default.
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- W157464434 date "2013-09-13" @default.
- W157464434 modified "2023-09-27" @default.
- W157464434 title "The Genetics of Pulmonary Fibrosis" @default.
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