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- W157464935 abstract "Neutral endopeptidase (EC 3.4.24.11, NEP) is a zinc-endopeptidase acting as ectoenzyme on the outer surface of brain cells and was found to be one of the major β-amyloid peptide (Aβ)-degrading enzymes. A malfunction of this enzyme has been postulated in the aetiology of Alzheimer’s disease (AD). Up-regulation of NEP in the brain prevents AD development by increasing Aβ clearance, resulting in a decrease of Aβ levels. Green tea and its constituents induced the specific activity of NEP in cultivated neuroblastoma cells without any significant effect on the similar angiotensin-converting enzyme. The increase of cellular NEP activity correlates to the increase of cAMP levels induced by the combination of epicatechin and epigallocatechin with methylxanthines like caffeine or theophylline. This induction effect depends not only on the differentiation improvement but also on the direct influence on NEP gene expression as well." @default.
- W157464935 created "2016-06-24" @default.
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- W157464935 date "2013-01-01" @default.
- W157464935 modified "2023-09-26" @default.
- W157464935 title "Effect of Green Tea Compounds on Neutral Endopeptidase Activity in Cultivated Brain Cells" @default.
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- W157464935 doi "https://doi.org/10.1016/b978-0-12-384937-3.00079-3" @default.
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