FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574656685> ?p ?o ?g. }

• W1574656685 endingPage "279" @default.
• W1574656685 startingPage "249" @default.
• W1574656685 abstract "Biological metabolites, substrates, cofactors, chemical probes, and drugs bind to flexible pockets in multiple biological macromolecules to exert their biological effect. The rapid growth of the structural databases and sequence data, including SNPs and disease-related genome modifications, complemented by the new cutting-edge 3D docking, scoring, and profiling methods has created a unique opportunity to develop a comprehensive structural map of interactions between any small molecule and biopolymers. Here we demonstrate that a comprehensive structural genomics engine can be built using multiple pocket conformations, experimentally determined or generated with a variety of modeling methods, and new efficient ensemble docking algorithms. In contrast to traditional ligand-activity-based engines trained on known chemical structures and their activities, the structural pocketome and docking engine will allow prediction of poses and activities for new, previously unknown, protein binding sites, and new, previously uncharacterized, chemical scaffolds. This de novo structure-based activity prediction engine may dramatically accelerate the discovery of potent and specific therapeutics with reduced side effects." @default.
• W1574656685 created "2016-06-24" @default.
• W1574656685 creator A5004550798 @default.
• W1574656685 creator A5064101943 @default.
• W1574656685 date "2009-01-01" @default.
• W1574656685 modified "2023-09-25" @default.
• W1574656685 title "The Flexible Pocketome Engine for Structural Chemogenomics" @default.
• W1574656685 cites W1554035625 @default.
• W1574656685 cites W1970208561 @default.
• W1574656685 cites W1970279759 @default.
• W1574656685 cites W1985028250 @default.
• W1574656685 cites W2003400191 @default.
• W1574656685 cites W2012969029 @default.
• W1574656685 cites W2020125455 @default.
• W1574656685 cites W2025836226 @default.
• W1574656685 cites W2027638447 @default.
• W1574656685 cites W2029087609 @default.
• W1574656685 cites W2045098692 @default.
• W1574656685 cites W2050066735 @default.
• W1574656685 cites W2060059149 @default.
• W1574656685 cites W2060094491 @default.
• W1574656685 cites W2061750520 @default.
• W1574656685 cites W2062081085 @default.
• W1574656685 cites W2066143642 @default.
• W1574656685 cites W2071500926 @default.
• W1574656685 cites W2087278791 @default.
• W1574656685 cites W2088347357 @default.
• W1574656685 cites W2094316817 @default.
• W1574656685 cites W2102376488 @default.
• W1574656685 cites W2112878061 @default.
• W1574656685 cites W2115339329 @default.
• W1574656685 cites W2120138074 @default.
• W1574656685 cites W2130479394 @default.
• W1574656685 cites W2131639373 @default.
• W1574656685 cites W2135817448 @default.
• W1574656685 cites W2145355174 @default.
• W1574656685 cites W2148694319 @default.
• W1574656685 cites W2160907977 @default.
• W1574656685 cites W2161062388 @default.
• W1574656685 cites W2163881579 @default.
• W1574656685 cites W2167041509 @default.
• W1574656685 cites W2170665326 @default.
• W1574656685 cites W2171074980 @default.
• W1574656685 cites W4240422054 @default.
• W1574656685 cites W4248012512 @default.
• W1574656685 cites W4296588184 @default.
• W1574656685 doi "https://doi.org/10.1007/978-1-60761-274-2_11" @default.
• W1574656685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2975493" @default.
• W1574656685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19727619" @default.
• W1574656685 hasPublicationYear "2009" @default.
• W1574656685 type Work @default.
• W1574656685 sameAs 1574656685 @default.
• W1574656685 citedByCount "50" @default.
• W1574656685 countsByYear W15746566852012 @default.
• W1574656685 countsByYear W15746566852013 @default.
• W1574656685 countsByYear W15746566852014 @default.
• W1574656685 countsByYear W15746566852015 @default.
• W1574656685 countsByYear W15746566852016 @default.
• W1574656685 countsByYear W15746566852017 @default.
• W1574656685 countsByYear W15746566852018 @default.
• W1574656685 countsByYear W15746566852019 @default.
• W1574656685 countsByYear W15746566852020 @default.
• W1574656685 countsByYear W15746566852021 @default.
• W1574656685 countsByYear W15746566852023 @default.
• W1574656685 crossrefType "book-chapter" @default.
• W1574656685 hasAuthorship W1574656685A5004550798 @default.
• W1574656685 hasAuthorship W1574656685A5064101943 @default.
• W1574656685 hasBestOaLocation W15746566852 @default.
• W1574656685 hasConcept C111919701 @default.
• W1574656685 hasConcept C159110408 @default.
• W1574656685 hasConcept C161624437 @default.
• W1574656685 hasConcept C185592680 @default.
• W1574656685 hasConcept C187191949 @default.
• W1574656685 hasConcept C192772702 @default.
• W1574656685 hasConcept C41008148 @default.
• W1574656685 hasConcept C41685203 @default.
• W1574656685 hasConcept C47701112 @default.
• W1574656685 hasConcept C55493867 @default.
• W1574656685 hasConcept C60644358 @default.
• W1574656685 hasConcept C70721500 @default.
• W1574656685 hasConcept C71924100 @default.
• W1574656685 hasConcept C74187038 @default.
• W1574656685 hasConcept C86803240 @default.
• W1574656685 hasConceptScore W1574656685C111919701 @default.
• W1574656685 hasConceptScore W1574656685C159110408 @default.
• W1574656685 hasConceptScore W1574656685C161624437 @default.
• W1574656685 hasConceptScore W1574656685C185592680 @default.
• W1574656685 hasConceptScore W1574656685C187191949 @default.
• W1574656685 hasConceptScore W1574656685C192772702 @default.
• W1574656685 hasConceptScore W1574656685C41008148 @default.
• W1574656685 hasConceptScore W1574656685C41685203 @default.
• W1574656685 hasConceptScore W1574656685C47701112 @default.
• W1574656685 hasConceptScore W1574656685C55493867 @default.
• W1574656685 hasConceptScore W1574656685C60644358 @default.
• W1574656685 hasConceptScore W1574656685C70721500 @default.
• W1574656685 hasConceptScore W1574656685C71924100 @default.
• W1574656685 hasConceptScore W1574656685C74187038 @default.
• W1574656685 hasConceptScore W1574656685C86803240 @default.

• next