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• W1574673451 endingPage "1743" @default.
• W1574673451 startingPage "1731" @default.
• W1574673451 abstract "Internal circadian clocks are important regulators of mammalian biology, acting to coordinate physiology and behaviour in line with daily changes in the environment. At present, synchronisation of the circadian system to the solar cycle is believed to rely on a quantitative assessment of total ambient illumination, provided by a bilateral projection from the retina to the suprachiasmatic nuclei (SCN). It is currently unclear, however, whether this photic integration occurs at the level of individual cells or within the SCN network. Here we use extracellular multielectrode recordings from the SCN of anaesthetised mice to show that most SCN neurons receive visual input from just one eye. While we find that binocular inputs to a subset of cells are important for rapid responses to changes in illumination, we find no evidence indicating that individual SCN cells are capable of reporting the average light intensity across the whole visual field. As a result of these local irradiance coding properties, our data establish that photic integration is primarily mediated at the level of the SCN network and suggest that accurate assessments of global light levels would be impaired by non-uniform illumination of either eye." @default.
• W1574673451 created "2016-06-24" @default.
• W1574673451 creator A5008883639 @default.
• W1574673451 creator A5051940814 @default.
• W1574673451 date "2015-02-27" @default.
• W1574673451 modified "2023-10-04" @default.
• W1574673451 title "Eye-specific visual processing in the mouse suprachiasmatic nuclei" @default.
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• W1574673451 doi "https://doi.org/10.1113/jphysiol.2014.288225" @default.
• W1574673451 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4386969" @default.
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• W1574673451 hasPublicationYear "2015" @default.
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