FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574722499> ?p ?o ?g. }

• W1574722499 endingPage "290" @default.
• W1574722499 startingPage "275" @default.
• W1574722499 abstract "Fungal cells are eliminated from animal hosts through oxidative stressmediated mechanisms. The ability to tolerate oxidative stress has been correlated with virulence in pathogenic fungi like Candida and Aspergillus species. The yeast Saccharomyces cerevisiae has served as an excellent model system for both fungal oxidative stress tolerance in particular and eukaryotic oxidant detoxification in general. A central determinant of oxidative-stress resistance in S. cerevisiae is the transcriptional activator protein Yaplp. Yaplp is normally found in the cytoplasm in the absence of oxidative stress but rapidly recruits to the nucleus upon challenge by oxidants such as H202 or diamide. Detailed mutagenesis and functional studies have demonstrated that two different cysteine-rich domains (CRDs) present in Yaplp are involved in detecting and responding to changes in the redox potential of the cell. The carboxy-terminal CRD (c-CRD) is sufficient to provide diamide regulation of nuclear localization to a chimeric green fluorescent protein (GFP) reporter fusion and contains an important nuclear export signal of Yaplp. Biochemical analyses have provided evidence that different folding states of Yaplp are found during diamide or H202 exposure. In the context of wild-type Yaplp, a second amino-terminal CRD (n-CRD) is required for normal regulation and function of Yaplp in response to H2O2 induced oxidative stress. Unlike the situation during diamide stress, correct folding of Yaplp in the presence of H2O2 requires the presence of ancillary factors like the glutathione peroxidase Gpx3p and the Yaplp-interacting protein Ybplp. While regulation of the nuclear export of Yaplp is a key modulatory step during both diamide and H2O2 induced oxidative stress, recent experiments have shown that a second feature of the H2O2 folded state of Yaplp is required to assure normal function in the presence of this oxidant. This review will summarize the state of understanding of oxidant-specific folding of Yaplp and the requirement for the folded state of Yaplp that is generated in the presence of H2O2 during the response to this oxidant." @default.
• W1574722499 created "2016-06-24" @default.
• W1574722499 creator A5039195342 @default.
• W1574722499 date "2008-01-01" @default.
• W1574722499 modified "2023-09-24" @default.
• W1574722499 title "Chapter 17 Oxidant-specific protein folding during fungal oxidative stress: Activation and function of the yaplp transcription factor in Saccharomyces cerevisiae" @default.
• W1574722499 cites W1527489814 @default.
• W1574722499 cites W1560585760 @default.
• W1574722499 cites W1578589309 @default.
• W1574722499 cites W1580930367 @default.
• W1574722499 cites W1911724401 @default.
• W1574722499 cites W1973252845 @default.
• W1574722499 cites W1977257051 @default.
• W1574722499 cites W1978794333 @default.
• W1574722499 cites W1982161126 @default.
• W1574722499 cites W1986790448 @default.
• W1574722499 cites W1994500027 @default.
• W1574722499 cites W1997313112 @default.
• W1574722499 cites W1998678765 @default.
• W1574722499 cites W2002734708 @default.
• W1574722499 cites W2004503571 @default.
• W1574722499 cites W2006861772 @default.
• W1574722499 cites W2008034988 @default.
• W1574722499 cites W2013947447 @default.
• W1574722499 cites W2018159372 @default.
• W1574722499 cites W2024431605 @default.
• W1574722499 cites W2038017519 @default.
• W1574722499 cites W2049446884 @default.
• W1574722499 cites W2052543312 @default.
• W1574722499 cites W2052893012 @default.
• W1574722499 cites W2055932567 @default.
• W1574722499 cites W2056269174 @default.
• W1574722499 cites W2057818847 @default.
• W1574722499 cites W2066515050 @default.
• W1574722499 cites W2074267752 @default.
• W1574722499 cites W2075149828 @default.
• W1574722499 cites W2075186587 @default.
• W1574722499 cites W2079662486 @default.
• W1574722499 cites W2090119499 @default.
• W1574722499 cites W2095422595 @default.
• W1574722499 cites W2099670854 @default.
• W1574722499 cites W2102585686 @default.
• W1574722499 cites W2106161171 @default.
• W1574722499 cites W2108668801 @default.
• W1574722499 cites W2123130100 @default.
• W1574722499 cites W2126916325 @default.
• W1574722499 cites W2131897418 @default.
• W1574722499 cites W2134909835 @default.
• W1574722499 cites W2137682724 @default.
• W1574722499 cites W2137683543 @default.
• W1574722499 cites W2141949196 @default.
• W1574722499 cites W2143402674 @default.
• W1574722499 cites W2149676146 @default.
• W1574722499 cites W2162042193 @default.
• W1574722499 cites W2167063768 @default.
• W1574722499 cites W2172022845 @default.
• W1574722499 cites W2185853395 @default.
• W1574722499 cites W32366060 @default.
• W1574722499 doi "https://doi.org/10.1016/s0275-0287(08)80059-8" @default.
• W1574722499 hasPublicationYear "2008" @default.
• W1574722499 type Work @default.
• W1574722499 sameAs 1574722499 @default.
• W1574722499 citedByCount "0" @default.
• W1574722499 crossrefType "book-chapter" @default.
• W1574722499 hasAuthorship W1574722499A5039195342 @default.
• W1574722499 hasConcept C104317684 @default.
• W1574722499 hasConcept C123894998 @default.
• W1574722499 hasConcept C190062978 @default.
• W1574722499 hasConcept C204328495 @default.
• W1574722499 hasConcept C2776151105 @default.
• W1574722499 hasConcept C2777576037 @default.
• W1574722499 hasConcept C2779222958 @default.
• W1574722499 hasConcept C2780114586 @default.
• W1574722499 hasConcept C40767141 @default.
• W1574722499 hasConcept C54757728 @default.
• W1574722499 hasConcept C55493867 @default.
• W1574722499 hasConcept C59157529 @default.
• W1574722499 hasConcept C86339819 @default.
• W1574722499 hasConcept C86803240 @default.
• W1574722499 hasConcept C95444343 @default.
• W1574722499 hasConceptScore W1574722499C104317684 @default.
• W1574722499 hasConceptScore W1574722499C123894998 @default.
• W1574722499 hasConceptScore W1574722499C190062978 @default.
• W1574722499 hasConceptScore W1574722499C204328495 @default.
• W1574722499 hasConceptScore W1574722499C2776151105 @default.
• W1574722499 hasConceptScore W1574722499C2777576037 @default.
• W1574722499 hasConceptScore W1574722499C2779222958 @default.
• W1574722499 hasConceptScore W1574722499C2780114586 @default.
• W1574722499 hasConceptScore W1574722499C40767141 @default.
• W1574722499 hasConceptScore W1574722499C54757728 @default.
• W1574722499 hasConceptScore W1574722499C55493867 @default.
• W1574722499 hasConceptScore W1574722499C59157529 @default.
• W1574722499 hasConceptScore W1574722499C86339819 @default.
• W1574722499 hasConceptScore W1574722499C86803240 @default.
• W1574722499 hasConceptScore W1574722499C95444343 @default.
• W1574722499 hasLocation W15747224991 @default.
• W1574722499 hasOpenAccess W1574722499 @default.
• W1574722499 hasPrimaryLocation W15747224991 @default.

• next