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• W1574803456 abstract "Pyrrolopyrimidine N-{4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-<I>d</I>]pyrimidin-5- yl)ethyl]benzoyl}-L-glutamic acid (LY231514), was shown to be an extremely potent antitumor agent with a locus of action distinctly different from that of 5,10-Dideazatetrahydrofolic acid (DDATHF) or lometrexol. The primary enzymatic target of this new compound was thymidylate synthase (TS) with secondary effects shown to include inhibition of aminoimidazole carboxamideribonucleotide- formyltransferase (AICARFT), 5,10-methylenetetrahydrofolate dehydrogenase, and 10-formyltetrahydrofolate synthetase. This new antitumor agent was thus a classical antifolate, but unique in its activity toward many different targets that control both transport and intracellular folate levels as a result of effects on cellular pyrimidine and purine biosynthesis. LY231514 was given the generic name pemetrexed disodium, and the proprietary name Alimta, and was approved by the FDA in early February 2004 for treatment of first line malignant pleural mesothelioma together with cisplatin. Alimta has received subsequent FDA approvals for non-squamous first line, second line, and maintenance therapy in non-small cell lung cancer (NSCLC)." @default.
• W1574803456 created "2016-06-24" @default.
• W1574803456 creator A5070242155 @default.
• W1574803456 date "2015-01-23" @default.
• W1574803456 modified "2023-10-16" @default.
• W1574803456 title "The Discovery of Alimta (Pemetrexed)" @default.
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• W1574803456 doi "https://doi.org/10.1002/9783527678433.ch8" @default.
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