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- W1574844930 abstract "Abstract Objectives: To investigate the independent association between the homeostasis model assessment of the insulin resistance (HOMA‐IR) score and rapid virological response (RVR) and sustained virological response (SVR) in chronic hepatitis C (CHC). Methods: Observational prospective cohort study of 412 CHC patients [59% males; mean age 45 years; genotype 1 (44%), 2 (32%), 3 (19%) and 4 (5%)] treated with pegylated interferon α plus ribavirin. Results: A HOMA‐IR ≥2.0 was present in 49% and a metabolic syndrome in 4% of patients. By multivariate analysis, independent predictors of SVR were the lack of advanced fibrosis (≥F3) in genotype 1 and a lower body mass index in genotype 3 patients. In the subgroup of patients in whom HCV‐RNA was evaluated at week 4 ( n =281), independent predictors of RVR were HCV‐RNA <700 000 IU/ml, age <40 years and lower aspartate aminotransferase:alanine aminotransferase ratio in genotype 1 and baseline HOMA‐IR ≤2 in genotype 3 patients. No predictive factor of RVR was identified among genotype 2 patients. RVR was the strongest predictor of SVR among genotype 1 or 3 patients. Conclusions: In this series of treatment‐naïve, Caucasian CHC patients at a low risk for the metabolic syndrome, HOMA‐IR is not a predictor of SVR, irrespective of the HCV genotype, although it may predict RVR in genotype 3 infection." @default.
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- W1574844930 date "2010-09-14" @default.
- W1574844930 modified "2023-10-16" @default.
- W1574844930 title "The homeostasis model assessment of the insulin resistance score is not predictive of a sustained virological response in chronic hepatitis C patients" @default.
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- W1574844930 doi "https://doi.org/10.1111/j.1478-3231.2010.02343.x" @default.
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