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- W1574845162 endingPage "e996025" @default.
- W1574845162 startingPage "e996025" @default.
- W1574845162 abstract "Evaluation of testicular functions (production of sperm and androgens) is an important aspect of preclinical safety assessment and testicular toxicity is comparatively far more common than ovarian toxicity. This chapter focuses (1) on the histological sequelae of disturbed reproductive endocrinology in rat, dog and nonhuman primates and (2) provides a review of our current understanding of the roles of gonadotropins and androgens. The response of the rodent testis to endocrine disturbances is clearly different from that of dog and primates with different germ cell types and spermatogenic stages being affected initially and also that the end-stage spermatogenic involution is more pronounced in dog and primates compared to rodents. Luteinizing hormone (LH)/testosterone and follicle-stimulating hormone (FSH) are the pivotal endocrine factors controlling testicular functions. The relative importance of either hormone is somewhat different between rodents and primates. Generally, however, both LH/testosterone and FSH are necessary for quantitatively normal spermatogenesis, at least in non-seasonal species." @default.
- W1574845162 created "2016-06-24" @default.
- W1574845162 creator A5005925910 @default.
- W1574845162 creator A5009601446 @default.
- W1574845162 date "2014-03-04" @default.
- W1574845162 modified "2023-10-13" @default.
- W1574845162 title "Endocrine control of spermatogenesis: Role of FSH and LH/ testosterone" @default.
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