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- W1574871937 abstract "Abstract Treatment of O 2 -exposed adult rats with low doses of bacterial endotoxin results in increased lung antioxidant enzyme activity and a marked protective effect against pulmonary O 2 toxicity. Since paraquat-induced lung damage is believed to be mediated by an O 2 free-radical mechanism, animals with increased lung antioxidant enzyme levels should better tolerate paraquat exposure. We therefore pre-exposed endotoxin-treated rats to hyperoxia for 48 hr and then administered a lethal dose (40 mg kg ) of paraquat to these animals and to non-O 2 -exposed rats. the O 2 -pre-exposed rats with elevated lung superoxide dismutase, catalase and glutathione peroxidase enzyme levels exhibited survival times after paraquat administration ( lt 50 = 7.25 days) that were prolonged more than 3-fold compared to the control, non-O 2 -pre-exposed rats that had received the same dose of paraquat ( lt 50 = 2.0 days). This animal model with increased biochemical defenses against potential hyper-oxidant toxicity may be of use in studying other toxic agents that produce lung damage through an O; free-radical mechanism." @default.
- W1574871937 created "2016-06-24" @default.
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- W1574871937 date "1981-08-01" @default.
- W1574871937 modified "2023-09-24" @default.
- W1574871937 title "Prolonged survival after paraquat" @default.
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- W1574871937 doi "https://doi.org/10.1016/0006-2952(81)90105-2" @default.
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