FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574967503> ?p ?o ?g. }

• W1574967503 endingPage "265" @default.
• W1574967503 startingPage "254" @default.
• W1574967503 abstract "Adipose tissue is an attractive source of mesenchymal stem/stromal cells (MSCs) with potential applications in reconstructive plastic surgery and regenerative medicine. The aim of this study was to characterise human adipose tissue MSCs (ASCs) derived from healthy individuals and cancer patients and to compare their interactions with tumour cells. ASCs were isolated from adipose tissue of healthy donors, breast cancer-adjacent adipose tissue of breast cancer patients and tumour-adjacent adipose tissue of non-breast cancer patients. Their proliferation, differentiation, immunophenotype and gene expression were assessed and effects on the proliferation of human breast cancer cell line MCF-7 compared. ASCs from all sources exhibited similar morphology, proliferative and differentiation potential, showing the characteristic pattern of mesenchymal surface markers expression (CD90, CD105, CD44H, CD73) and the lack of HLA-DR and hematopoietic markers (CD11a, CD33, CD45, Glycophorin-CD235a), but uneven expression of CD34. ASCs also shared a common positive gene expression of HLA-DR, HLA-A, IL-6, TGF-β and HIF-1, but were negative for HLA-G, while the expression levels of Cox-2 and IDO-1 varied. All ASCs significantly stimulated the proliferation of MCF-7 tumour cells in direct mixed co-cultures and transwell system, although their conditioned media displayed antiproliferative activity. Data obtained showed that ASCs with similar characteristics are easily isolated from various donors and sites of origin, although ASCs could both suppress and favour tumour cells growth, emphasising the importance of cellular context within the microenvironment and pointing to the significance of safety studies to exclude any potential clinical risk of their application in regenerative medicine." @default.
• W1574967503 created "2016-06-24" @default.
• W1574967503 creator A5009685607 @default.
• W1574967503 creator A5011613244 @default.
• W1574967503 creator A5040234095 @default.
• W1574967503 creator A5046041410 @default.
• W1574967503 creator A5048577279 @default.
• W1574967503 creator A5066883045 @default.
• W1574967503 creator A5070089375 @default.
• W1574967503 creator A5075625978 @default.
• W1574967503 creator A5082293737 @default.
• W1574967503 creator A5090272429 @default.
• W1574967503 date "2013-11-15" @default.
• W1574967503 modified "2023-09-23" @default.
• W1574967503 title "Characteristics of human adipose mesenchymal stem cells isolated from healthy and cancer affected people and their interactions with human breast cancer cell line M <scp>CF</scp> ‐7 in vitro" @default.
• W1574967503 cites W1529762633 @default.
• W1574967503 cites W19461481 @default.
• W1574967503 cites W1965727192 @default.
• W1574967503 cites W1972938311 @default.
• W1574967503 cites W1990419270 @default.
• W1574967503 cites W1994594051 @default.
• W1574967503 cites W2007098561 @default.
• W1574967503 cites W2010822486 @default.
• W1574967503 cites W2015648727 @default.
• W1574967503 cites W2015963176 @default.
• W1574967503 cites W2018028722 @default.
• W1574967503 cites W2025371271 @default.
• W1574967503 cites W2029864259 @default.
• W1574967503 cites W2044233644 @default.
• W1574967503 cites W2054134729 @default.
• W1574967503 cites W2069027997 @default.
• W1574967503 cites W2076704745 @default.
• W1574967503 cites W2080433269 @default.
• W1574967503 cites W2087353148 @default.
• W1574967503 cites W2090037913 @default.
• W1574967503 cites W2092746470 @default.
• W1574967503 cites W2105151699 @default.
• W1574967503 cites W2113247673 @default.
• W1574967503 cites W2115062578 @default.
• W1574967503 cites W2124117129 @default.
• W1574967503 cites W2130229338 @default.
• W1574967503 cites W2136869217 @default.
• W1574967503 cites W2145261297 @default.
• W1574967503 cites W2161544223 @default.
• W1574967503 cites W2161905225 @default.
• W1574967503 cites W4231972389 @default.
• W1574967503 doi "https://doi.org/10.1002/cbin.10198" @default.
• W1574967503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24155046" @default.
• W1574967503 hasPublicationYear "2013" @default.
• W1574967503 type Work @default.
• W1574967503 sameAs 1574967503 @default.
• W1574967503 citedByCount "27" @default.
• W1574967503 countsByYear W15749675032014 @default.
• W1574967503 countsByYear W15749675032015 @default.
• W1574967503 countsByYear W15749675032016 @default.
• W1574967503 countsByYear W15749675032017 @default.
• W1574967503 countsByYear W15749675032018 @default.
• W1574967503 countsByYear W15749675032019 @default.
• W1574967503 countsByYear W15749675032021 @default.
• W1574967503 countsByYear W15749675032022 @default.
• W1574967503 countsByYear W15749675032023 @default.
• W1574967503 crossrefType "journal-article" @default.
• W1574967503 hasAuthorship W1574967503A5009685607 @default.
• W1574967503 hasAuthorship W1574967503A5011613244 @default.
• W1574967503 hasAuthorship W1574967503A5040234095 @default.
• W1574967503 hasAuthorship W1574967503A5046041410 @default.
• W1574967503 hasAuthorship W1574967503A5048577279 @default.
• W1574967503 hasAuthorship W1574967503A5066883045 @default.
• W1574967503 hasAuthorship W1574967503A5070089375 @default.
• W1574967503 hasAuthorship W1574967503A5075625978 @default.
• W1574967503 hasAuthorship W1574967503A5082293737 @default.
• W1574967503 hasAuthorship W1574967503A5090272429 @default.
• W1574967503 hasConcept C10205521 @default.
• W1574967503 hasConcept C116716535 @default.
• W1574967503 hasConcept C121608353 @default.
• W1574967503 hasConcept C126322002 @default.
• W1574967503 hasConcept C134018914 @default.
• W1574967503 hasConcept C142724271 @default.
• W1574967503 hasConcept C16930146 @default.
• W1574967503 hasConcept C171089720 @default.
• W1574967503 hasConcept C198826908 @default.
• W1574967503 hasConcept C203014093 @default.
• W1574967503 hasConcept C28328180 @default.
• W1574967503 hasConcept C502942594 @default.
• W1574967503 hasConcept C530470458 @default.
• W1574967503 hasConcept C55427017 @default.
• W1574967503 hasConcept C71924100 @default.
• W1574967503 hasConcept C86803240 @default.
• W1574967503 hasConcept C95444343 @default.
• W1574967503 hasConcept C96232424 @default.
• W1574967503 hasConceptScore W1574967503C10205521 @default.
• W1574967503 hasConceptScore W1574967503C116716535 @default.
• W1574967503 hasConceptScore W1574967503C121608353 @default.
• W1574967503 hasConceptScore W1574967503C126322002 @default.
• W1574967503 hasConceptScore W1574967503C134018914 @default.
• W1574967503 hasConceptScore W1574967503C142724271 @default.
• W1574967503 hasConceptScore W1574967503C16930146 @default.
• W1574967503 hasConceptScore W1574967503C171089720 @default.

• next