Matches in SemOpenAlex for { <https://semopenalex.org/work/W1574994574> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W1574994574 endingPage "72" @default.
- W1574994574 startingPage "66" @default.
- W1574994574 abstract "Summary A study on the effects of various antibiotics on enterobacterial lipopolysaccharides and hemagglutination and hemolysis revealed the following results: Small amounts of polymyxin B (1–1.25 μg/ml) and neomycin (12.5–15 μg/ml) and larger amounts of humycin (50–100 μg/ml) and streptomycin (40–125 μg/ml) inhibit enterobacterial hemagglutination and hemolysis if the antibiotics are added to highly purified lipopolysaccharide (5 μg/ml) prior to modification of sheep red blood cells. Somewhat larger amounts are required for inhibition with less highly purified lipopolysaccharides and crude preparations.Bacitracin (2500 μg/ml), penicillin (1000 μg/ml), erythromycin (1000 μg/ml), and novobiocin (500 μg/ml) have no such effect.Polymyxin B, neomycin, humycin, and streptomycin do not inhibit hemagglutination and hemolysis of previously modified red blood cells.Treatment of red blood cells with the antibiotics prior to modification does not prevent hemagglutination and hemolysis by homologous bacterial antibody and complement.Treatment of human red blood cells of blood group A with mixtures of antibiotics (polymyxin B or neomycin), S. sonnei lipopolysaccharide, and S. sonnei antibodies of human origin does not inhibit hemagglutination by blood group A antiserum, indicating that the red blood cells had not become inagglutinable. Coombs antiserum does not cause hemagglutination of these treated red blood cells.Polymyxin B, neomycin, humycin, and streptomycin do not abolish antibody neutralizing capacity of enterobacterial lipopolysaccharides in hemolysis inhibition tests, although a slight degree of inhibition was found.It is tentatively concluded that polymyxin B, neomycin, humycin, and streptomycin interfere with the attachment of lipopolysaccharides to the surface of red blood cells and, to a lesser degree, cause alteration of their antibody reacting capacity.The significance of the results is discussed with particular reference to the possible specificity of the action of antibiotics on enterobacterial lipopolysaccharides and the bearing of the findings on the mode of action of the antibiotics." @default.
- W1574994574 created "2016-06-24" @default.
- W1574994574 creator A5010842915 @default.
- W1574994574 creator A5021968441 @default.
- W1574994574 creator A5069668228 @default.
- W1574994574 creator A5089167748 @default.
- W1574994574 date "1958-01-01" @default.
- W1574994574 modified "2023-10-14" @default.
- W1574994574 title "The Effects of Antibiotics on Enterobacterial Lipopolysaccharides (Endotoxins), Hemagglutination and Hemolysis" @default.
- W1574994574 doi "https://doi.org/10.4049/jimmunol.80.1.66" @default.
- W1574994574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13514073" @default.
- W1574994574 hasPublicationYear "1958" @default.
- W1574994574 type Work @default.
- W1574994574 sameAs 1574994574 @default.
- W1574994574 citedByCount "29" @default.
- W1574994574 countsByYear W15749945742014 @default.
- W1574994574 crossrefType "journal-article" @default.
- W1574994574 hasAuthorship W1574994574A5010842915 @default.
- W1574994574 hasAuthorship W1574994574A5021968441 @default.
- W1574994574 hasAuthorship W1574994574A5069668228 @default.
- W1574994574 hasAuthorship W1574994574A5089167748 @default.
- W1574994574 hasBestOaLocation W15749945741 @default.
- W1574994574 hasConcept C159654299 @default.
- W1574994574 hasConcept C174802600 @default.
- W1574994574 hasConcept C182072434 @default.
- W1574994574 hasConcept C185592680 @default.
- W1574994574 hasConcept C203014093 @default.
- W1574994574 hasConcept C2775843808 @default.
- W1574994574 hasConcept C2778754761 @default.
- W1574994574 hasConcept C2779841869 @default.
- W1574994574 hasConcept C2779860364 @default.
- W1574994574 hasConcept C2779902561 @default.
- W1574994574 hasConcept C2780026444 @default.
- W1574994574 hasConcept C2780675486 @default.
- W1574994574 hasConcept C32611913 @default.
- W1574994574 hasConcept C34343649 @default.
- W1574994574 hasConcept C501593827 @default.
- W1574994574 hasConcept C86803240 @default.
- W1574994574 hasConcept C89423630 @default.
- W1574994574 hasConcept C91523082 @default.
- W1574994574 hasConceptScore W1574994574C159654299 @default.
- W1574994574 hasConceptScore W1574994574C174802600 @default.
- W1574994574 hasConceptScore W1574994574C182072434 @default.
- W1574994574 hasConceptScore W1574994574C185592680 @default.
- W1574994574 hasConceptScore W1574994574C203014093 @default.
- W1574994574 hasConceptScore W1574994574C2775843808 @default.
- W1574994574 hasConceptScore W1574994574C2778754761 @default.
- W1574994574 hasConceptScore W1574994574C2779841869 @default.
- W1574994574 hasConceptScore W1574994574C2779860364 @default.
- W1574994574 hasConceptScore W1574994574C2779902561 @default.
- W1574994574 hasConceptScore W1574994574C2780026444 @default.
- W1574994574 hasConceptScore W1574994574C2780675486 @default.
- W1574994574 hasConceptScore W1574994574C32611913 @default.
- W1574994574 hasConceptScore W1574994574C34343649 @default.
- W1574994574 hasConceptScore W1574994574C501593827 @default.
- W1574994574 hasConceptScore W1574994574C86803240 @default.
- W1574994574 hasConceptScore W1574994574C89423630 @default.
- W1574994574 hasConceptScore W1574994574C91523082 @default.
- W1574994574 hasIssue "1" @default.
- W1574994574 hasLocation W15749945741 @default.
- W1574994574 hasLocation W15749945742 @default.
- W1574994574 hasOpenAccess W1574994574 @default.
- W1574994574 hasPrimaryLocation W15749945741 @default.
- W1574994574 hasRelatedWork W116036847 @default.
- W1574994574 hasRelatedWork W1433044369 @default.
- W1574994574 hasRelatedWork W1515275343 @default.
- W1574994574 hasRelatedWork W1574994574 @default.
- W1574994574 hasRelatedWork W1973637769 @default.
- W1574994574 hasRelatedWork W2048915724 @default.
- W1574994574 hasRelatedWork W2331896424 @default.
- W1574994574 hasRelatedWork W2423702044 @default.
- W1574994574 hasRelatedWork W2432904232 @default.
- W1574994574 hasRelatedWork W3152059165 @default.
- W1574994574 hasVolume "80" @default.
- W1574994574 isParatext "false" @default.
- W1574994574 isRetracted "false" @default.
- W1574994574 magId "1574994574" @default.
- W1574994574 workType "article" @default.