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• W1575023142 startingPage "7065" @default.
• W1575023142 abstract "In response to retinal disease and injury, the axon terminals of rod photoreceptors demonstrate dramatic structural plasticity, including axonal retraction, neurite extension, and the development of presynaptic varicosities. Cone cell terminals, however, are relatively inactive. Similar events are observed in primary cultures of salamander photoreceptors. To investigate the mechanisms underlying these disparate presynaptic responses, antagonists to voltage-gated L-type and cGMP-gated channels, known to be present on rod and cone cell terminals, respectively, were used to block calcium influx during critical periods of plasticity <i>in vitro</i>. In rod cells, L-type channel antagonists nicardipine and verapamil inhibited not only the outgrowth of processes and the formation of varicosities, but also the synthesis of vesicle proteins, SV2 and synaptophysin. In contrast, the synthesis of opsin in rod cells was unaffected. In cone cells, L-type channel antagonists caused only modest changes. However, cobalt bromide, which blocks all calcium channels, andl-<i>cis-</i>diltiazem, a potent antagonist of cGMP-gated channels, significantly inhibited varicosity formation and synthesis of SV2 in cone cells. Moreover, the cGMP-gated channel agonist 8-bromo-cGMP caused a significant increase in varicosity formation by cone but not rod cells. Thus voltage-gated L-type channels in rod cells and cGMP-gated channels in cone cells are the primary calcium channels required for structural plasticity and the accompanying upregulation of synaptic vesicle synthesis. The differing responses of rod and cone terminals to injury and disease may be determined by these differences in the regulation of Ca²⁺ influx." @default.
• W1575023142 created "2016-06-24" @default.
• W1575023142 creator A5009318195 @default.
• W1575023142 creator A5090654043 @default.
• W1575023142 date "2002-08-15" @default.
• W1575023142 modified "2023-09-25" @default.
• W1575023142 title "Regulation of Structural Plasticity by Different Channel Types in Rod and Cone Photoreceptors" @default.
• W1575023142 cites W100217110 @default.
• W1575023142 cites W1483863652 @default.
• W1575023142 cites W1489308828 @default.
• W1575023142 cites W1490352649 @default.
• W1575023142 cites W1496131947 @default.
• W1575023142 cites W1498567414 @default.
• W1575023142 cites W1509665006 @default.
• W1575023142 cites W1544777143 @default.
• W1575023142 cites W1587310874 @default.
• W1575023142 cites W1676740452 @default.
• W1575023142 cites W1778649086 @default.
• W1575023142 cites W1873545359 @default.
• W1575023142 cites W1915525585 @default.
• W1575023142 cites W1919086687 @default.
• W1575023142 cites W1949292176 @default.
• W1575023142 cites W1964080157 @default.
• W1575023142 cites W1964454692 @default.
• W1575023142 cites W1968780955 @default.
• W1575023142 cites W1981515471 @default.
• W1575023142 cites W1981541219 @default.
• W1575023142 cites W1982336887 @default.
• W1575023142 cites W1987836596 @default.
• W1575023142 cites W1991570498 @default.
• W1575023142 cites W1992529363 @default.
• W1575023142 cites W1993172106 @default.
• W1575023142 cites W1994109113 @default.
• W1575023142 cites W1997547096 @default.
• W1575023142 cites W1997668305 @default.
• W1575023142 cites W2000252657 @default.
• W1575023142 cites W2001072141 @default.
• W1575023142 cites W2002029595 @default.
• W1575023142 cites W2007324297 @default.
• W1575023142 cites W2008537587 @default.
• W1575023142 cites W2013861261 @default.
• W1575023142 cites W2016773845 @default.
• W1575023142 cites W2018633041 @default.
• W1575023142 cites W2019674303 @default.
• W1575023142 cites W2023004062 @default.
• W1575023142 cites W2026439974 @default.
• W1575023142 cites W2029390749 @default.
• W1575023142 cites W2034224805 @default.
• W1575023142 cites W2035465014 @default.
• W1575023142 cites W2045534857 @default.
• W1575023142 cites W2049480397 @default.
• W1575023142 cites W2051721076 @default.
• W1575023142 cites W2051985278 @default.
• W1575023142 cites W2054431330 @default.
• W1575023142 cites W2057235202 @default.
• W1575023142 cites W2059433193 @default.
• W1575023142 cites W2059671927 @default.
• W1575023142 cites W2069790062 @default.
• W1575023142 cites W2072919410 @default.
• W1575023142 cites W2078335821 @default.
• W1575023142 cites W2081501675 @default.
• W1575023142 cites W2082882836 @default.
• W1575023142 cites W2085220858 @default.
• W1575023142 cites W2086662540 @default.
• W1575023142 cites W2087758815 @default.
• W1575023142 cites W2092360229 @default.
• W1575023142 cites W2101072772 @default.
• W1575023142 cites W2104732707 @default.
• W1575023142 cites W2104870434 @default.
• W1575023142 cites W2111855919 @default.
• W1575023142 cites W2112520390 @default.
• W1575023142 cites W2117316542 @default.
• W1575023142 cites W2119544072 @default.
• W1575023142 cites W2128248687 @default.
• W1575023142 cites W2129963552 @default.
• W1575023142 cites W2135011583 @default.
• W1575023142 cites W2142437847 @default.
• W1575023142 cites W2156029588 @default.
• W1575023142 cites W2157727199 @default.
• W1575023142 cites W2170897236 @default.
• W1575023142 cites W2176431604 @default.
• W1575023142 cites W2186674126 @default.
• W1575023142 cites W2221620327 @default.
• W1575023142 cites W2395431563 @default.
• W1575023142 cites W2416930944 @default.
• W1575023142 cites W2424884300 @default.
• W1575023142 cites W4230753364 @default.
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• W1575023142 doi "https://doi.org/10.1523/jneurosci.22-16-07065.2002" @default.
• W1575023142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757881" @default.
• W1575023142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12177203" @default.
• W1575023142 hasPublicationYear "2002" @default.
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