FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1575136927> ?p ?o ?g. }

• W1575136927 abstract "Exosomes represent a distinct class of membrane nanovesicles of endocytic origin that are released to the extracellular microenvironment from diverse cell types under both physiological and pathological conditions. Remarkable roles of exosomes have been revealed in intercellular communication, immune regulation, infection, aging and cancer. Exosomes carry and transfer proteins, nucleic acids and lipids, and are ubiquitous in most biofluids, such as urine, plasma, cerebrospinal fluid, etc. Membrane vesicles secreted by the epithelial cells of the urinary tract hold the promise to be an excellent source of disease relevant cargo proteins. In clinical proteomics urine is one of the most attractive biofluids as it can be obtained non-invasively, in large quantities and is relatively stable. Current isolation methods however are not sufficiently proficient to produce urinary exosomes (UEs) at a purity grade and with reproducibility suitable for downstream LC-MS based quantitative proteomics applications. Consequently urinary exosome based protein biomarker research today exclusively relies on targeted protein studies (Table 1). This chapter describes the current state-of-the-art in exosome research in general and urinary exosomes in particular with a special focus on the potential of UEs in protein biomarker discovery. Recently we have developed an improved isolation/purification method based on double-cushion sucrose/D2O ultracentrifugation (Raj et al., 2011b). The method relies on the solubilization of the major impurities associated with UEs in a carefully selected buffer solution. The new method separates exosomes from the heavier membrane fragments and/or vesicles more efficiently than current protocols and is compatible with LC-MS-based quantitative proteomics workflow." @default.
• W1575136927 created "2016-06-24" @default.
• W1575136927 creator A5007438174 @default.
• W1575136927 creator A5022303490 @default.
• W1575136927 creator A5034689878 @default.
• W1575136927 creator A5067556462 @default.
• W1575136927 date "2012-02-10" @default.
• W1575136927 modified "2023-09-23" @default.
• W1575136927 title "Urinary Exosomes for Protein Biomarker Research" @default.
• W1575136927 cites W148454370 @default.
• W1575136927 cites W1605178647 @default.
• W1575136927 cites W1762620449 @default.
• W1575136927 cites W1843137073 @default.
• W1575136927 cites W1889489351 @default.
• W1575136927 cites W1965774359 @default.
• W1575136927 cites W1969738372 @default.
• W1575136927 cites W1980593265 @default.
• W1575136927 cites W1988249798 @default.
• W1575136927 cites W1990741894 @default.
• W1575136927 cites W1997442983 @default.
• W1575136927 cites W2019917125 @default.
• W1575136927 cites W2028797002 @default.
• W1575136927 cites W2030209163 @default.
• W1575136927 cites W2038509755 @default.
• W1575136927 cites W2051678321 @default.
• W1575136927 cites W2055313665 @default.
• W1575136927 cites W2057155093 @default.
• W1575136927 cites W2060551353 @default.
• W1575136927 cites W2076264204 @default.
• W1575136927 cites W2076740795 @default.
• W1575136927 cites W2077005121 @default.
• W1575136927 cites W2078424563 @default.
• W1575136927 cites W2080143331 @default.
• W1575136927 cites W2086077027 @default.
• W1575136927 cites W2086704388 @default.
• W1575136927 cites W2106782182 @default.
• W1575136927 cites W2111019629 @default.
• W1575136927 cites W2111778115 @default.
• W1575136927 cites W2115926089 @default.
• W1575136927 cites W2119764013 @default.
• W1575136927 cites W2119906582 @default.
• W1575136927 cites W2120016245 @default.
• W1575136927 cites W2124663458 @default.
• W1575136927 cites W2129062330 @default.
• W1575136927 cites W2137051799 @default.
• W1575136927 cites W2145380430 @default.
• W1575136927 cites W2147524926 @default.
• W1575136927 cites W2149574286 @default.
• W1575136927 cites W2152915643 @default.
• W1575136927 cites W2155401787 @default.
• W1575136927 cites W2161318755 @default.
• W1575136927 cites W2162778644 @default.
• W1575136927 cites W2168326351 @default.
• W1575136927 cites W2169550143 @default.
• W1575136927 cites W2170114979 @default.
• W1575136927 cites W2171672500 @default.
• W1575136927 doi "https://doi.org/10.5772/30094" @default.
• W1575136927 hasPublicationYear "2012" @default.
• W1575136927 type Work @default.
• W1575136927 sameAs 1575136927 @default.
• W1575136927 citedByCount "1" @default.
• W1575136927 countsByYear W15751369272014 @default.
• W1575136927 crossrefType "book-chapter" @default.
• W1575136927 hasAuthorship W1575136927A5007438174 @default.
• W1575136927 hasAuthorship W1575136927A5022303490 @default.
• W1575136927 hasAuthorship W1575136927A5034689878 @default.
• W1575136927 hasAuthorship W1575136927A5067556462 @default.
• W1575136927 hasBestOaLocation W15751369271 @default.
• W1575136927 hasConcept C104317684 @default.
• W1575136927 hasConcept C126322002 @default.
• W1575136927 hasConcept C145059251 @default.
• W1575136927 hasConcept C185592680 @default.
• W1575136927 hasConcept C20518536 @default.
• W1575136927 hasConcept C2781197716 @default.
• W1575136927 hasConcept C55493867 @default.
• W1575136927 hasConcept C71924100 @default.
• W1575136927 hasConcept C77411442 @default.
• W1575136927 hasConceptScore W1575136927C104317684 @default.
• W1575136927 hasConceptScore W1575136927C126322002 @default.
• W1575136927 hasConceptScore W1575136927C145059251 @default.
• W1575136927 hasConceptScore W1575136927C185592680 @default.
• W1575136927 hasConceptScore W1575136927C20518536 @default.
• W1575136927 hasConceptScore W1575136927C2781197716 @default.
• W1575136927 hasConceptScore W1575136927C55493867 @default.
• W1575136927 hasConceptScore W1575136927C71924100 @default.
• W1575136927 hasConceptScore W1575136927C77411442 @default.
• W1575136927 hasLocation W15751369271 @default.
• W1575136927 hasLocation W15751369272 @default.
• W1575136927 hasOpenAccess W1575136927 @default.
• W1575136927 hasPrimaryLocation W15751369271 @default.
• W1575136927 hasRelatedWork W190693332 @default.
• W1575136927 hasRelatedWork W1992146223 @default.
• W1575136927 hasRelatedWork W2114662782 @default.
• W1575136927 hasRelatedWork W2118583622 @default.
• W1575136927 hasRelatedWork W2258705012 @default.
• W1575136927 hasRelatedWork W2406164672 @default.
• W1575136927 hasRelatedWork W2412574627 @default.
• W1575136927 hasRelatedWork W2517659937 @default.
• W1575136927 hasRelatedWork W4235671009 @default.
• W1575136927 hasRelatedWork W4288392727 @default.

• next