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• W1575142502 abstract "OBJECTIVE: To investigate grey (GM) and white matter (WM) abnormalities in patients with primary focal dystonia and if such changes are related to clinical features BACKGROUND: Conventional MRI studies suggest that primary focal dystonia is not accompanied by structural brain abnormalities. Voxel-based morphometry and diffusion tensor (DT) MRI reported inconsistent findings on GM and WM damage in these patients. DESIGN/METHODS: 3D T1-weighted and DT MRI scans were obtained from 75 patients with focal dystonia (20 blepharospasm [BL], 15 spasmodic disphonia [SD], 21 spasmodic torticollis [ST], 19 writer’s cramp [WC]) and 83 healthy controls. RESULTS: Patients with BL showed decreased GM in the right postcentral gyrus, rolandic operculum, bilateral cerebellum and left supramarginal and parahippocampal gyri, which was associated with clinical severity. SD patients showed decreased GM in bilateral superior frontal gyrus, and bilateral rolandic operculum/insula and right temporal lobe compared to controls. WC patients did not show regions of GM decrease but GM increases were found in the right middle frontal gyrus and insula, left superior frontal and postcentral gyri, as well as in bilateral thalami. In WC, GM increase of the left supramarginal gyrus was associated with disease duration and WC rating scale movement score. The comparison between ST and controls showed no GM difference. Compared with controls, BL and SD patients showed a widespread pattern of WM damage. Increased mean diffusivity and decreased fractional anisotropy of the right internal and external capsule were found in ST and WC patients. No relationship was observed between WM damage and disease severity and duration in dystonia patients. CONCLUSIONS: Patients with focal dystonia exhibit GM and WM alterations in regions highly relevant to motor function, sensory processing, and cognitive modulation of motor behavior. These abnormalities may contribute to the understanding of the clinical features of focal dystonia. Study Supported by: MPNS #175090 grant Disclosure: Dr. Sarro has received personal compensation for activities with Bayer Schering. Dr. Caso has nothing to disclose. Dr. Agosta has received personal compensation for activities with Bayer Pharmaceuticals Corporation, Biogen Idec, Sanofi-Aventis Pharmaceuticals Inc., and Serono Symposia International Foundation. Dr. Agosta has received personal compensation in an editorial capacity for the Journal of Neurology. Dr. Agosta has received research support from the Italian Ministry of Health, and Teva Neuroscience. Dr. Galantucci has nothing to disclose. Dr. Tomic has nothing to disclose. Dr. Svetel has received personal compensation for activities with Lundbeck, Novartis, GlaxoSmithKline Inc. and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Kresojevic has nothing to disclose. Dr. Comi has received personal compensation for activities with Sanofi-Aventis Pharmaceuticals Inc., Novartis, Merck Serono, Biogen Idec, Bayer Pharmaceuticals Corp., Teva Neuroscience, and Actellion. Dr. Kostic has received personal compensation for activities with Boehringer Ingelheim Pharmaceuticals Inc., Pfizer Inc., Solvay Pharmaceuticals, Novartis, Abbott, Hemofarm Stada, and GlaxoSmithKline Inc. Dr. Kostic has received research support from Hemofarm Stada, Lundbeck, Novartis, GlaxoSmithKline Inc., Pharma Swiss, Boehringer Ingelheim Pharmaceuticals Inc., Bayer Pharmaceuticals Corp., and Pfizer Inc. Dr. Filippi has received personal compensation for activities with Teva Neuroscience and Genmab AS as a member of scientific advisory boards, and Bayer Pharmaceuticals Corp. as a consultant. Dr. Filippi has received research support from Bayer Schering, Biogen Idec, Genmab AS, Merck Serono, Teva Neuroscience, the Italian Ministry of Health, and the Fondazione Italiana Sclerosi Mult." @default.
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• W1575142502 date "2014-04-08" @default.
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• W1575142502 title "Brain Structural Changes In Primary Focal Dystonia (P2.045)" @default.
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