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- W1575158045 abstract "Electron microscopic studies extending over the past decade have led to significant advances in knowledge of the biology of the melanocyte (1, 2, 3, 4). Certain problems, however, remain outstanding, foremost among which is that concerning the exact nature of the relationship between the melanocyte and another epidermal component, the cell of Langerhans (5, 6, 7). Some workers (8, 9) deny that any such relationship exists, but there is considerable evidence which suggests that the Langerhans cell is either a worn-out melanocyte in the process of being desquamated (10, 11) or, possibly, one of the division products of a mature melanocyte which never engages in melanogenesis and is .expendable (12). Examination of fetal skin at a period when immature melanocytes are present in appreciable numbers and multiplying within the basal layer of the epidermis might well be expected to throw further light on this question of the origin and nature of the Langerhans cell. It is of interest to establish if, indeed, these cells are present in the skin at this stage of development, and if they already contain the characteristic cytoplasmic organelles, the nature and mode of formation of which is obscure (7). If the Langerhans cell is, in fact, related to the melanocyte, transitional forms containing pre-melanosomes (precursor melanin granules) and characteristic Langerhans cell granules together in the cytoplasm might be encountered. Such intermediate type cells are not found in fully developed epidermis (6)." @default.
- W1575158045 created "2016-06-24" @default.
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- W1575158045 date "1965-01-01" @default.
- W1575158045 modified "2023-09-24" @default.
- W1575158045 title "Electron Microscopy of Melanocytes and Langerhans Cells in Human Fetal Epidermis at Fourteen Weeks**From the Department of Anatomy, St. Mary's Hospital Medical School (University of London), London W.2., England" @default.
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- W1575158045 doi "https://doi.org/10.1038/jid.1965.11" @default.
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