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- W1575161698 abstract "Genomic studies of the nonpathogenic budding yeast Saccharomyces cerevisiae are proving to be highly applicable to antifungal drug discovery. Paradigms derived from S. cerevisiae studies will continue to direct C. albicans research and contribute to one's understanding of fungal pathogenesis and the identification of antifungal drug targets. Many of these resources and their corresponding technologies have direct applications to antifungal drug discovery, but perhaps the most relevant resource is the yeast deletion mutant set. A discussion of how to exploit the knowledge of both essential genes and biological networks containing nonessential genes to identify drug targets is provided in this chapter. Because chemical-genetic profiling focuses on compounds that impair cell growth, it can also be applied to natural-product extracts, which often contain only one growth-inhibitory active compound. Identification of the set of essential yeast genes is one of the most important results to immediately fall out of the deletion project because it immediately defined ~1,000 candidate antifungal targets. In summary, the chapter highlights the incredible power of combining systematic genetics with antifungal drug target identification. In particular, the availability of a complete barcoded set of deletion mutants, including conditional alleles of essential genes, for the major fungal pathogens would permit identification of the “universal fungal essential gene set,” allow a broad application of chemical genomics in these organisms, and enable a systematic analysis of phenotypes associated with pathogenicity." @default.
- W1575161698 created "2016-06-24" @default.
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- W1575161698 date "2014-04-08" @default.
- W1575161698 modified "2023-09-24" @default.
- W1575161698 title "Functional Genomic Approaches to Fungal Pathogenesis, Drug Target Validation, and Antifungal Drug Discovery" @default.
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- W1575161698 doi "https://doi.org/10.1128/9781555815776.ch42" @default.
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