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- W1575176480 abstract "Reactive oxygen species (ROS) are produced under oxidative stress, such as high oxygen concentration and during the metabolic consumption of oxygen molecules. Male reproductive tissues appear to be continuously exposed to ROS produced by active metabolism. In addition, spermatozoa must pass through a high oxygen environment during the mating process. Thus, to maintain viable reproductive ability, a protective mechanism against oxidative stress is of importance. Here, we overview our current understanding of the cooperative function of antioxidative and redox systems that are involved in male fertility. Superoxide dismutase and glutathione peroxidase are major enzymes that scavenge harmful ROS in male reproductive organs. In turn, glutathione and thioredoxin systems constitute the main redox systems that repair oxidized and damaged molecules and also play a role in regulating a variety of cellular functions. While glutathione functions as an antioxidant by donating electrons to glutathione peroxidase and thioredoxin donates electrons to peroxiredoxin as a counterpart of glutathione peroxidase. In addition, aldo-keto reductases, which detoxify carbonyl compounds produced by oxidative stress, are present at high levels in the epithelia of the genital tract and Sertoli cells of the testis. Since these systems are involved in cross-talk, a comprehensive understanding will be required to maintain the physiological functions of male reproductive system." @default.
- W1575176480 created "2016-06-24" @default.
- W1575176480 creator A5016269675 @default.
- W1575176480 creator A5018663683 @default.
- W1575176480 creator A5038502891 @default.
- W1575176480 creator A5066654204 @default.
- W1575176480 date "2003-09-01" @default.
- W1575176480 modified "2023-09-23" @default.
- W1575176480 title "Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues." @default.
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- W1575176480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12937808" @default.