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- W1575233455 abstract "The disturbance of the hypothalamic-pituitary- adrenal axis characteristic of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is likely to affect brain development, yet neuroanatomic work is only beginning. Fetal hyperandrogenemia in 46, XX 21-OHD leads to masculinized brain organization and, consequently, at later stages of development, to masculinized gender-related behavior and cognitive function, including, although relatively uncommonly, gender identity. Genital masculinization as well as its surgical treatment has implications for social stigmatization and sexual functioning. CAH-associated electrolyte crises in infancy and later may result in severe cognitive impairment. Psychiatric disorders are somewhat increased, especially in patients with severe degrees of CAH." @default.
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- W1575233455 date "2010-12-16" @default.
- W1575233455 modified "2023-09-25" @default.
- W1575233455 title "Brain Development and Cognitive, Psychosocial, and Psychiatric Functioning in Classical 21- Hydroxylase Deficiency" @default.
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- W1575233455 doi "https://doi.org/10.1159/000321225" @default.
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