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• W1575461149 endingPage "2032" @default.
• W1575461149 startingPage "2027" @default.
• W1575461149 abstract "A hydrophobic, redox-active component with a molecular mass of 538 Da was isolated from lyophilized membranes of Methanosarcina mazei Gö1 by extraction with isooctane. After purification on a high-performance liquid chromatography column, the chemical structure was analyzed by mass spectroscopy and nuclear magnetic resonance studies. The component was called methanophenazine and represents a 2-hydroxyphenazine derivative which is connected via an ether bridge to a polyisoprenoid side chain. Since methanophenazine was almost insoluble in aqueous buffers, water-soluble phenazine derivatives were tested for their ability to interact with membrane-bound enzymes involved in electron transport and energy conservation. The purified F42OH2 dehydrogenase from M. mazei Gö1 showed highest activity with 2-hydroxyphenazine and 2-bromophenazine as electron acceptors when F420H2 was added. Phenazine-1-carboxylic acid and phenazine proved to be less effective. The Km values for 2-hydroxyphenazine and phenazine were 35 and 250 microM, respectively. 2-Hydroxyphenazine was also reduced by molecular hydrogen catalyzed by an F420-nonreactive hydrogenase which is present in washed membrane preparations. Furthermore, the membrane-bound heterodisulfide reductase was able to use reduced 2-hydroxyphenazine as an electron donor for the reduction of CoB-S-S-CoM. Considering all these results, it is reasonable to assume that methanophenazine plays an important role in vivo in membrane-bound electron transport of M. mazei Gö1." @default.
• W1575461149 created "2016-06-24" @default.
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• W1575461149 date "1998-04-15" @default.
• W1575461149 modified "2023-10-01" @default.
• W1575461149 title "Isolation and Characterization of Methanophenazine and Function of Phenazines in Membrane-Bound Electron Transport of<i>Methanosarcina mazei</i>Gö1" @default.
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• W1575461149 doi "https://doi.org/10.1128/jb.180.8.2027-2032.1998" @default.
• W1575461149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/107126" @default.
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• W1575461149 hasPublicationYear "1998" @default.
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