FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1575485780> ?p ?o ?g. }

• W1575485780 endingPage "62" @default.
• W1575485780 startingPage "47" @default.
• W1575485780 abstract "Transcription factor GATA-1 is essential for erythroid cell differentiation. GATA-binding motifs have been found in the regulatory regions of various erythroid-specific genes, suggesting that GATA-1 contributes to gene regulation during the entire process of erythropoiesis. A GATA-1 germ-line mutation results in embryonic lethality due to defective primitive erythropoiesis and GATA-1-null embryonic stem cells fails to differentiate beyond the proerythroblast stage. Therefore, the precise roles of GATA-1 in the later stages of erythropoiesis could not be clarified. Under the control of a GATA-1 gene hematopoietic regulatory domain, a GATA-1 mutant lacking the N-finger domain (DeltaNF mutant) was over-expressed in mice. These mice exhibited abnormal morphology in peripheral red blood cells (RBCs), reticulocytosis, splenomegaly, and erythroid hyperplasia, indicating compensated hemolysis. These mice were extremely sensitive to phenylhydrazine (PHZ), an agent that induces hemolysis, and their RBCs were osmotically fragile. Importantly, the hemolytic response to PHZ was partially restored by the simultaneous expression of wild-type GATA-1 with the DeltaNF mutant, supporting our contention that DeltaNF protein competitively inhibits the function of endogenous GATA-1. These data provide the first in vivo evidence that the NF domain contributes to the gene regulation that is critical for differentiation and survival of mature RBCs in postnatal erythropoiesis." @default.
• W1575485780 created "2016-06-24" @default.
• W1575485780 creator A5002377181 @default.
• W1575485780 creator A5018165237 @default.
• W1575485780 creator A5023421402 @default.
• W1575485780 creator A5029484313 @default.
• W1575485780 creator A5036696793 @default.
• W1575485780 creator A5045447879 @default.
• W1575485780 creator A5050775793 @default.
• W1575485780 creator A5054549197 @default.
• W1575485780 creator A5059173132 @default.
• W1575485780 creator A5067388920 @default.
• W1575485780 creator A5082466891 @default.
• W1575485780 creator A5088062381 @default.
• W1575485780 date "2004-12-21" @default.
• W1575485780 modified "2023-09-23" @default.
• W1575485780 title "Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells" @default.
• W1575485780 cites W152209846 @default.
• W1575485780 cites W1894677829 @default.
• W1575485780 cites W1973595140 @default.
• W1575485780 cites W1976386009 @default.
• W1575485780 cites W1977508213 @default.
• W1575485780 cites W1981460612 @default.
• W1575485780 cites W1982468817 @default.
• W1575485780 cites W1990627671 @default.
• W1575485780 cites W1992621257 @default.
• W1575485780 cites W1998607972 @default.
• W1575485780 cites W2001772277 @default.
• W1575485780 cites W2002511984 @default.
• W1575485780 cites W2011759872 @default.
• W1575485780 cites W2016149299 @default.
• W1575485780 cites W2017192222 @default.
• W1575485780 cites W2023737187 @default.
• W1575485780 cites W2024520070 @default.
• W1575485780 cites W2037253018 @default.
• W1575485780 cites W2054338068 @default.
• W1575485780 cites W2054816172 @default.
• W1575485780 cites W2063222008 @default.
• W1575485780 cites W2063692850 @default.
• W1575485780 cites W2071000969 @default.
• W1575485780 cites W2071238021 @default.
• W1575485780 cites W2074378056 @default.
• W1575485780 cites W2076153728 @default.
• W1575485780 cites W2086548325 @default.
• W1575485780 cites W2089019735 @default.
• W1575485780 cites W2091247151 @default.
• W1575485780 cites W2093631087 @default.
• W1575485780 cites W2100726754 @default.
• W1575485780 cites W2102508584 @default.
• W1575485780 cites W2130487814 @default.
• W1575485780 cites W2133980334 @default.
• W1575485780 cites W2138804685 @default.
• W1575485780 cites W2143615866 @default.
• W1575485780 cites W2147951044 @default.
• W1575485780 cites W2151396228 @default.
• W1575485780 cites W2156495603 @default.
• W1575485780 cites W2159424962 @default.
• W1575485780 cites W21629621 @default.
• W1575485780 cites W2413483753 @default.
• W1575485780 cites W4242911221 @default.
• W1575485780 doi "https://doi.org/10.1111/j.1365-2443.2005.00814.x" @default.
• W1575485780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15670213" @default.
• W1575485780 hasPublicationYear "2004" @default.
• W1575485780 type Work @default.
• W1575485780 sameAs 1575485780 @default.
• W1575485780 citedByCount "12" @default.
• W1575485780 countsByYear W15754857802012 @default.
• W1575485780 countsByYear W15754857802013 @default.
• W1575485780 countsByYear W15754857802014 @default.
• W1575485780 countsByYear W15754857802016 @default.
• W1575485780 countsByYear W15754857802020 @default.
• W1575485780 crossrefType "journal-article" @default.
• W1575485780 hasAuthorship W1575485780A5002377181 @default.
• W1575485780 hasAuthorship W1575485780A5018165237 @default.
• W1575485780 hasAuthorship W1575485780A5023421402 @default.
• W1575485780 hasAuthorship W1575485780A5029484313 @default.
• W1575485780 hasAuthorship W1575485780A5036696793 @default.
• W1575485780 hasAuthorship W1575485780A5045447879 @default.
• W1575485780 hasAuthorship W1575485780A5050775793 @default.
• W1575485780 hasAuthorship W1575485780A5054549197 @default.
• W1575485780 hasAuthorship W1575485780A5059173132 @default.
• W1575485780 hasAuthorship W1575485780A5067388920 @default.
• W1575485780 hasAuthorship W1575485780A5082466891 @default.
• W1575485780 hasAuthorship W1575485780A5088062381 @default.
• W1575485780 hasBestOaLocation W15754857801 @default.
• W1575485780 hasConcept C101762097 @default.
• W1575485780 hasConcept C102230213 @default.
• W1575485780 hasConcept C104317684 @default.
• W1575485780 hasConcept C109159458 @default.
• W1575485780 hasConcept C126322002 @default.
• W1575485780 hasConcept C142455686 @default.
• W1575485780 hasConcept C143065580 @default.
• W1575485780 hasConcept C145103041 @default.
• W1575485780 hasConcept C150194340 @default.
• W1575485780 hasConcept C153911025 @default.
• W1575485780 hasConcept C2777799521 @default.
• W1575485780 hasConcept C2778248108 @default.
• W1575485780 hasConcept C2779703530 @default.

• next