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- W1575611446 abstract "Introduction: Myocardial infarction results in the death of large numbers of cardiomyocytes which are not replaced. We have recently identified a protein, Hypoxia and Akt induced Stem cell Factor (HASF), which inhibits cardiomyocyte apoptosis and promotes the proliferation of these cells. Although the therapeutic effects of HASF were clearly demonstrated, critical aspects of the signaling pathway, namely the identity of the receptor, were unclear. Here, we report that HASF binds and signals through the Insulin-like Growth Factor-1 Receptor (IGF-1R). Methods: Mouse cardiomyocytes were isolated by the Langendorff technique. Yeast two-hybrid and co-immunoprecipitation were used to identify HASF binding proteins. Kinase activation and GLUT4 translocation were assessed by immunoblot analysis. Results: A yeast two-hybrid screen identified a partial fragment of the IGF-1R as a binding partner of HASF. Direct interaction between HASF and the full-length IGF-1R was subsequently identified via co-immunoprecipitatio..." @default.
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- W1575611446 date "2014-11-25" @default.
- W1575611446 modified "2023-09-24" @default.
- W1575611446 title "Abstract 15731: Hypoxia and Akt Induced Stem Cell Factor Exerts Cardioprotective Effects via Specific Binding to the Insulin-Like Growth Factor-1 Receptor" @default.
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