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- W1575751520 abstract "Abstract IL-19 is a proinflammatory cytokine that belongs to the IL-10 cytokine family. In addition to its known connection with psoriasis, previous work in our lab along with others, have also shown its association with asthma. Using cultured primary mouse airway cells, we demonstrated that Th2 cytokines such as IL-4 and IL-13 can induce the expression of IL-19 mRNA. In a mouse OVA-induced asthma model, we showed that IL-19 expression is increased in lung tissue during early disease stages. Additionally, we observed that other IL-10 family members such as IL-20, IL-22, or IL-24, were not induced. We further identified that airway epithelial cells, rather than the alveolar macrophage, were the source of IL-19 in the asthma model. Although we show that IL-19 can promote Th2 cytokine production by activated T cells, restimulation with IL-19 does not further increase Th2 cytokine production on memory cells. This phenomenon correlates with a down-regulation of IL-20R2 when cells are differentiated in the presence of IL-19, indicating a negative feedback regulatory mechanism. These results demonstrate that IL-19 is produced by airway epithelial cells during the early stage of the asthmatic response, and may further amplify the Th2 response by acting on activated T cells recruited to the lung during later disease stages by inducing Th2 cytokine production." @default.
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- W1575751520 date "2010-04-01" @default.
- W1575751520 modified "2023-09-26" @default.
- W1575751520 title "Early expression of IL-19 in asthmatic airways promotes Th2 response (141.5)" @default.
- W1575751520 doi "https://doi.org/10.4049/jimmunol.184.supp.141.5" @default.
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