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• W1575798687 abstract "Abstract The replication initiator protein (gene II protein (gpII] of bacteriophage f1 is a multifunctional protein that plays central roles in initiation and termination of phage DNA replication. It introduces a nick at a specific site on the (+)-strand of supercoiled replicative form DNA. The 3'-hydroxyl end of the nick serves as the primer for (+)-strand rolling-circle replication. Upon completion of a round of synthesis, gpII cleaves and circulaizes the displaced single strand. When Mn2+ is included in the buffer instead of Mg2+, gpII cleaves both strands. In this paper, we investigate the mechanism of the Mn2+-dependent double-strand cleavage activity of gpII. This reaction, unlike nicking in the presence of Mg2+, does not require superhelicity. The reaction proceeds in two kinetic steps: first nicking of the (+)-strand, and then cleavage of the (-)-strand. The nucleotide sequence requirement for nicking is reduced compared to that in the presence of Mg2+. The product of the double-strand cleavage has an unusual structure. The left end is a telomere-like hairpin since the (+)- and (-)-strands are joined, as demonstrated by base sequencing. The right end has a onebase 3'-overhang. This reaction probably reflects the cleavage-joining activity of gpII in the termination event." @default.
• W1575798687 created "2016-06-24" @default.
• W1575798687 creator A5066960553 @default.
• W1575798687 creator A5075608631 @default.
• W1575798687 date "1989-07-01" @default.
• W1575798687 modified "2023-09-28" @default.
• W1575798687 title "Double-strand Cleavage and Strand Joining by the Replication Initiator Protein of Filamentous Phage f1" @default.
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• W1575798687 doi "https://doi.org/10.1016/s0021-9258(18)63902-x" @default.
• W1575798687 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2663862" @default.
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