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- W1575817874 abstract "<h2>Abstract</h2> The local anesthetic lidocaine was studied for its effects on lipid metabolism in aortas from normal rats, rabbits, and cholesterol-fed (atherosclerotic) rabbits in vitro. Incubation of aortas in the presence of 3–5 mM lidocaine resulted in a statistically significant reduction in the incorporation of [<sup>14</sup>C]oleate into cholesteryl esters and phosphatidylcholine. Additionally, significant increases in [<sup>14</sup>C]oleate incorporation into the diglyceride fraction of atheromatous rabbit aortas was observed with a trend to greater incorporation into the diglyceride fraction of normal rat and rabbit arteries as well. The most significant overall effect of lidocaine was its inhibition (50–90%) of the arterial sterol esterification. Assays of acylCoA : cholesterol acyltransferase (ACAT, EC 2.3.1.26) in isolated arterial microsomes revealed that, in addition to local anesthetics (e.g., lidocaine), other membrane-active agents such as chlorpromazine and methoxyflurane inhibit ACAT; this suggests ACAT may be regulated by alterations in the biophysical properties of its membrane milieu." @default.
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- W1575817874 date "1981-07-01" @default.
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- W1575817874 title "Membrane-active agents" @default.
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- W1575817874 doi "https://doi.org/10.1016/0021-9150(81)90009-5" @default.
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