Matches in SemOpenAlex for { <https://semopenalex.org/work/W1575862435> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1575862435 endingPage "2067" @default.
- W1575862435 startingPage "2058" @default.
- W1575862435 abstract "Abstract CR2, a 145,000 to 150,000 Mr protein which binds specific breakdown products of C3, has been identified on the surface of both human and murine B cells. In order to understand the evolutionary relatedness of the human and murine proteins, we have used the coding sequences from the human CR2 gene to investigate those homologous sequences of murine Cr2. Human CR2 cDNA sequences were used as probes on a cDNA library derived from BALB/c spleen mRNA to identify cross-reacting cDNA sequences. A number of putative cDNA clones encoding murine Cr2 have been isolated and examined. DNA sequence analysis of these Cr2 cDNA clones indicates that they represent the murine homolog to human CR2. mRNA analysis with these Cr2 cDNA clones has revealed a transcription pattern similar to, but distinct from that seen for CR2. Whereas human CR2 coding sequences identify a single mRNA species of approximately 5 kb from human tonsillar mRNA, the murine counterpart identifies four transcripts from murine spleen of approximately 3, 5, 9 and 11 kb in size. The Cr2 cDNA clones which detect the four forms of spleen mRNA overlap in coding sequences and contain exons mapping to three colinear fragments as defined by EcoRI digestion. This suggests that the 3- 5-, 9-, and 11-kb mRNA forms arise by alternative splicing from a single gene. Use of these murine Cr2-specific cDNA clones to isolate their respective genomic sequences has allowed for the linkage of the 3' end of the Cr2 gene to the 5' end of the Crry gene, the evolutionary homolog to human CR1." @default.
- W1575862435 created "2016-06-24" @default.
- W1575862435 creator A5027515228 @default.
- W1575862435 creator A5028316558 @default.
- W1575862435 creator A5033504409 @default.
- W1575862435 creator A5068196876 @default.
- W1575862435 date "1989-09-15" @default.
- W1575862435 modified "2023-09-26" @default.
- W1575862435 title "Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry." @default.
- W1575862435 doi "https://doi.org/10.4049/jimmunol.143.6.2058" @default.
- W1575862435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2528587" @default.
- W1575862435 hasPublicationYear "1989" @default.
- W1575862435 type Work @default.
- W1575862435 sameAs 1575862435 @default.
- W1575862435 citedByCount "27" @default.
- W1575862435 countsByYear W15758624352012 @default.
- W1575862435 countsByYear W15758624352016 @default.
- W1575862435 countsByYear W15758624352020 @default.
- W1575862435 crossrefType "journal-article" @default.
- W1575862435 hasAuthorship W1575862435A5027515228 @default.
- W1575862435 hasAuthorship W1575862435A5028316558 @default.
- W1575862435 hasAuthorship W1575862435A5033504409 @default.
- W1575862435 hasAuthorship W1575862435A5068196876 @default.
- W1575862435 hasBestOaLocation W15758624351 @default.
- W1575862435 hasConcept C104317684 @default.
- W1575862435 hasConcept C105580179 @default.
- W1575862435 hasConcept C150194340 @default.
- W1575862435 hasConcept C153911025 @default.
- W1575862435 hasConcept C17757408 @default.
- W1575862435 hasConcept C187882448 @default.
- W1575862435 hasConcept C189482833 @default.
- W1575862435 hasConcept C194583182 @default.
- W1575862435 hasConcept C19924922 @default.
- W1575862435 hasConcept C36823959 @default.
- W1575862435 hasConcept C50724178 @default.
- W1575862435 hasConcept C54355233 @default.
- W1575862435 hasConcept C54458228 @default.
- W1575862435 hasConcept C67705224 @default.
- W1575862435 hasConcept C86803240 @default.
- W1575862435 hasConcept C91779695 @default.
- W1575862435 hasConceptScore W1575862435C104317684 @default.
- W1575862435 hasConceptScore W1575862435C105580179 @default.
- W1575862435 hasConceptScore W1575862435C150194340 @default.
- W1575862435 hasConceptScore W1575862435C153911025 @default.
- W1575862435 hasConceptScore W1575862435C17757408 @default.
- W1575862435 hasConceptScore W1575862435C187882448 @default.
- W1575862435 hasConceptScore W1575862435C189482833 @default.
- W1575862435 hasConceptScore W1575862435C194583182 @default.
- W1575862435 hasConceptScore W1575862435C19924922 @default.
- W1575862435 hasConceptScore W1575862435C36823959 @default.
- W1575862435 hasConceptScore W1575862435C50724178 @default.
- W1575862435 hasConceptScore W1575862435C54355233 @default.
- W1575862435 hasConceptScore W1575862435C54458228 @default.
- W1575862435 hasConceptScore W1575862435C67705224 @default.
- W1575862435 hasConceptScore W1575862435C86803240 @default.
- W1575862435 hasConceptScore W1575862435C91779695 @default.
- W1575862435 hasIssue "6" @default.
- W1575862435 hasLocation W15758624351 @default.
- W1575862435 hasLocation W15758624352 @default.
- W1575862435 hasOpenAccess W1575862435 @default.
- W1575862435 hasPrimaryLocation W15758624351 @default.
- W1575862435 hasRelatedWork W1966427723 @default.
- W1575862435 hasRelatedWork W1980617967 @default.
- W1575862435 hasRelatedWork W1994241126 @default.
- W1575862435 hasRelatedWork W2003903343 @default.
- W1575862435 hasRelatedWork W2009810944 @default.
- W1575862435 hasRelatedWork W2035178353 @default.
- W1575862435 hasRelatedWork W2035923258 @default.
- W1575862435 hasRelatedWork W2044804548 @default.
- W1575862435 hasRelatedWork W2071606798 @default.
- W1575862435 hasRelatedWork W4313221961 @default.
- W1575862435 hasVolume "143" @default.
- W1575862435 isParatext "false" @default.
- W1575862435 isRetracted "false" @default.
- W1575862435 magId "1575862435" @default.
- W1575862435 workType "article" @default.