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- W1575874727 abstract "Spines and dendrites of central neurons represent an important site of synaptic signaling and integration. Here we identify a new, synaptically mediated spine signal with unique properties. Using two-photon Na + imaging, we show that suprathreshold synaptic stimulation leads to transient increases in Na + concentration in postsynaptic spines and their adjacent dendrites. This local signal is restricted to a dendritic domain near the site of synaptic input. In presumed active spines within this domain, the Na + level increases by 30–40 m m even during short bursts of synaptic stimulation. During a long-term potentiation induction protocol (100 Hz, 1 sec), the Na + level in the active spines reaches peak amplitudes of ∼100 m m . We find that the Na + transients are mainly mediated by Na + entry through NMDA receptor channels and are detected during the coincident occurrence of synaptic potentials and backpropagating action potentials. The large amplitudes of the Na + transients and their location on dendritic spines suggest that this signal is an important determinant of electrical and biochemical spine characteristics." @default.
- W1575874727 created "2016-06-24" @default.
- W1575874727 creator A5002256276 @default.
- W1575874727 creator A5004662891 @default.
- W1575874727 date "2001-06-15" @default.
- W1575874727 modified "2023-10-11" @default.
- W1575874727 title "NMDA Receptor-Mediated Na<sup>+</sup>Signals in Spines and Dendrites" @default.
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- W1575874727 doi "https://doi.org/10.1523/jneurosci.21-12-04207.2001" @default.
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