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- W1575878930 abstract "Optimal placental blood flow is essential for materno-fetal nutrient exchange. Aberrant placental perfusion is associated with growth restriction and pre-eclampsia. Placental vascularity varies from the placental centre to periphery, as histologically, increased spiral artery remodelling is evident in the centre. This has not been demonstrated in vivo with any imaging technique. MRI permits a larger field of view than ultrasound and has the ability to acquire the whole placenta in a single acquisition. We hypothesised that MRI can be used to objectively quantify placental blood flow. MRI (1.5 T Philips Achieva) was performed at 24–26 weeks and at 34–36 weeks in 5 women. A respiratory-gated, standard diffusion, pulsed-spin echo sequence was used to acquire 5 transverse slices including the whole placenta and repeated 5 times. A region of interest was drawn around the whole placenta and the fractional moving blood volume (f) was calculated using the IVIM equation in Matlab. The central slice was defined independently by 2 observers. A single observer traced all 5 slices of each placenta. The intra-observer ICC of whole placental measurements for both observers, independent of gestation, was > 0.9. Intra-observer limits of agreement for measurements made by observer 1 ranged at ± 17% and observer 2 at ± 18%. Inter-observer ICC for the whole placental measurement, regardless of gestation was > 0.86. Limits of agreement were wider and ranged from − 50% to 60%. The mean f of peripheral slices, independent of gestation, was 0.044 compared to 0.069 for central slices. The ratio of f between the central and peripheral slices increased from 1 : 1 at 24–26 weeks to 1.7 : 1.0 at 34–36 weeks although this change was not significant (P = 0.23). MRI can be used to reliably acquire and quantify the fractional moving blood volume within the placenta. Placental blood flow appears to be higher in the centre of the placenta than at the periphery. MRI has the ability to identify differences in placental perfusion and could be used to quantify pathophysiological processes." @default.
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- W1575878930 date "2011-09-14" @default.
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- W1575878930 title "OC10.03: MRI assessment of regional fractional moving blood volume within the placenta" @default.
- W1575878930 doi "https://doi.org/10.1002/uog.9147" @default.
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