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• W1575897758 abstract "Summary 1.The effect of cholestane-3β,5α,6β-triol (CT), diformate ester of CT (CTDF) and β-sitosterol on the absorption of [4- 14 C] cholesterol was studied by using thoracic duct fistulated rats. CT and β-sitosterol depressed the absorption of labeled cholesterol when they were given at a dosage equal to that of cholesterol. 2.The effects of CT on the incorporation of labeled acetate into cholesterol and fatty acids were studied in both liver slices and intact rats. In the liver slice system, CT induced specifically a remarkable enhancement of hepatic cholesterogenesis. The enhancing effect of CT on hepatic cholesterogenesis was far less pronounced in intact rats. 3.CT increased the fecalexcretion of sterols and fatty acids in rats. The increased excretion of the fecal sterols was also induced in bile duct-ligated or -fistulated rats. 4.CT and CTDF induced the increased fecal excretion and lesser body retention of the radioactivity following the injection of labeled cholesterol to rats. The fecal cholesterol/bile acid ratio was increased 0.61 to 2.43 by the daily administration of CT. 5.CT revealed little or no influence on the biliary excretion of the labeled cholesterol given to the bile duct fistulated rats. 6.CT reduced the radioactivity in hepatic cholesterol and simultaneously increased the radioactivity of the small intestine following the administration of labeled cholesterol to rats. These results suggest that the hypocholesterolemic action of CT results from increased fecal sterol excretion due to inhibition of the intestinal absorption of cholesterol and/or increased excretion through the intestinal route." @default.
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• W1575897758 date "1967-09-01" @default.
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• W1575897758 title "Biological studies of cholestane-3β,5α,6β-triol and its derivatives" @default.
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• W1575897758 doi "https://doi.org/10.1016/s0368-1319(67)80043-7" @default.
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