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- W1576112648 abstract "Vesicular tethers and SNAREs are two key protein components that govern docking and fusion of intracellular membrane carriers in eukaryotic cells. The conserved oligomeric Golgi (COG) complex has been specifically implicated in the tethering of retrograde intra-Golgi vesicles. Using yeast two-hybrid and co-immunoprecipitation approaches, we show that the COG6 subunit of the COG complex is capable of interacting with a subset of Golgi SNAREs, namely STX5, STX6, GS27 and SNAP29. Interaction with SNAREs is accomplished via the universal SNARE-binding motif of COG6. Overexpression of COG6, or its depletion from cells, disrupts the integrity of the Golgi complex. Importantly, COG6 protein lacking the SNARE-binding domain is deficient in Golgi binding, and is not capable of inducing Golgi complex fragmentation when overexpressed. These results indicate that COG6-SNARE interactions are important for both COG6 localization and Golgi integrity." @default.
- W1576112648 created "2016-06-24" @default.
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- W1576112648 date "2012-11-12" @default.
- W1576112648 modified "2023-09-27" @default.
- W1576112648 title "COG6 Interacts with a Subset of the Golgi SNAREs and Is Important for the Golgi Complex Integrity" @default.
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- W1576112648 doi "https://doi.org/10.1111/tra.12020" @default.
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