Matches in SemOpenAlex for { <https://semopenalex.org/work/W1576140147> ?p ?o ?g. }
- W1576140147 endingPage "182" @default.
- W1576140147 startingPage "169" @default.
- W1576140147 abstract "NPR1, a master regulator of basal and systemic acquired resistance in plants, confers immunity through a transcriptional cascade, which includes transcription activators (e.g., TGA3) and repressors (e.g., WRKY70), leading to the massive induction of antimicrobial genes. How this single protein orchestrates genome-wide transcriptional reprogramming in response to immune stimulus remains a major question. Paradoxically, while NPR1 is essential for defense gene induction, its turnover appears to be required for this function, suggesting that NPR1 activity and degradation are dynamically regulated. Here we show that sumoylation of NPR1 by SUMO3 activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA transcription activators. Sumoylation also triggers NPR1 degradation, rendering the immune induction transient. SUMO modification of NPR1 is inhibited by phosphorylation at Ser55/Ser59, which keeps NPR1 stable and quiescent. Thus, posttranslational modifications enable dynamic but tight and precise control of plant immune responses." @default.
- W1576140147 created "2016-06-24" @default.
- W1576140147 creator A5007291340 @default.
- W1576140147 creator A5011301116 @default.
- W1576140147 creator A5036872396 @default.
- W1576140147 creator A5051797292 @default.
- W1576140147 creator A5057480063 @default.
- W1576140147 creator A5064631835 @default.
- W1576140147 creator A5069259200 @default.
- W1576140147 creator A5081653989 @default.
- W1576140147 creator A5086336516 @default.
- W1576140147 creator A5090976283 @default.
- W1576140147 date "2015-08-01" @default.
- W1576140147 modified "2023-10-18" @default.
- W1576140147 title "Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses" @default.
- W1576140147 cites W1503575803 @default.
- W1576140147 cites W1959908262 @default.
- W1576140147 cites W1966975589 @default.
- W1576140147 cites W1976732528 @default.
- W1576140147 cites W1979275431 @default.
- W1576140147 cites W1980168194 @default.
- W1576140147 cites W1986606670 @default.
- W1576140147 cites W1988031203 @default.
- W1576140147 cites W1992161351 @default.
- W1576140147 cites W2003199010 @default.
- W1576140147 cites W2013108773 @default.
- W1576140147 cites W2023183725 @default.
- W1576140147 cites W2026053299 @default.
- W1576140147 cites W2027372593 @default.
- W1576140147 cites W2030132680 @default.
- W1576140147 cites W2033993360 @default.
- W1576140147 cites W2044229112 @default.
- W1576140147 cites W2047134964 @default.
- W1576140147 cites W2058553280 @default.
- W1576140147 cites W2073148985 @default.
- W1576140147 cites W2083124566 @default.
- W1576140147 cites W2084144301 @default.
- W1576140147 cites W2103794175 @default.
- W1576140147 cites W2112441454 @default.
- W1576140147 cites W2113033976 @default.
- W1576140147 cites W2114570899 @default.
- W1576140147 cites W2115771825 @default.
- W1576140147 cites W2116122104 @default.
- W1576140147 cites W2120470126 @default.
- W1576140147 cites W2129568627 @default.
- W1576140147 cites W2133640187 @default.
- W1576140147 cites W2133825089 @default.
- W1576140147 cites W2134030532 @default.
- W1576140147 cites W2137007437 @default.
- W1576140147 cites W2138693996 @default.
- W1576140147 cites W2139170657 @default.
- W1576140147 cites W2142415992 @default.
- W1576140147 cites W2147321004 @default.
- W1576140147 cites W2148937130 @default.
- W1576140147 cites W2151910428 @default.
- W1576140147 cites W2153536602 @default.
- W1576140147 cites W2156219697 @default.
- W1576140147 cites W2158367220 @default.
- W1576140147 cites W2162702318 @default.
- W1576140147 cites W2168969893 @default.
- W1576140147 cites W2171788269 @default.
- W1576140147 cites W4240574505 @default.
- W1576140147 doi "https://doi.org/10.1016/j.chom.2015.07.005" @default.
- W1576140147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4537515" @default.
- W1576140147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26269953" @default.
- W1576140147 hasPublicationYear "2015" @default.
- W1576140147 type Work @default.
- W1576140147 sameAs 1576140147 @default.
- W1576140147 citedByCount "181" @default.
- W1576140147 countsByYear W15761401472016 @default.
- W1576140147 countsByYear W15761401472017 @default.
- W1576140147 countsByYear W15761401472018 @default.
- W1576140147 countsByYear W15761401472019 @default.
- W1576140147 countsByYear W15761401472020 @default.
- W1576140147 countsByYear W15761401472021 @default.
- W1576140147 countsByYear W15761401472022 @default.
- W1576140147 countsByYear W15761401472023 @default.
- W1576140147 crossrefType "journal-article" @default.
- W1576140147 hasAuthorship W1576140147A5007291340 @default.
- W1576140147 hasAuthorship W1576140147A5011301116 @default.
- W1576140147 hasAuthorship W1576140147A5036872396 @default.
- W1576140147 hasAuthorship W1576140147A5051797292 @default.
- W1576140147 hasAuthorship W1576140147A5057480063 @default.
- W1576140147 hasAuthorship W1576140147A5064631835 @default.
- W1576140147 hasAuthorship W1576140147A5069259200 @default.
- W1576140147 hasAuthorship W1576140147A5081653989 @default.
- W1576140147 hasAuthorship W1576140147A5086336516 @default.
- W1576140147 hasAuthorship W1576140147A5090976283 @default.
- W1576140147 hasBestOaLocation W15761401471 @default.
- W1576140147 hasConcept C104317684 @default.
- W1576140147 hasConcept C126322002 @default.
- W1576140147 hasConcept C138885662 @default.
- W1576140147 hasConcept C150194340 @default.
- W1576140147 hasConcept C158448853 @default.
- W1576140147 hasConcept C162317418 @default.
- W1576140147 hasConcept C171350616 @default.
- W1576140147 hasConcept C179926584 @default.
- W1576140147 hasConcept C25602115 @default.