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- W1576231096 abstract "To understand and promote vascular health, we must reduce the aggression to the vessel wall and enhance the physiologic mechanisms leading to restoration of vessel wall function. Three main defense mechanisms are responsible for maintaining cardiovascular homeostasis: the regenerative production of endothelial progenitor cells, vessel wall angiogenesis, and macrophage-mediated reverse cholesterol transport. Endothelial progenitor cells can restore vessel wall function and reduce atherosclerosis. In patients with risk factors, high levels of circulating progenitor cells increase event-free survival from cardiovascular events. Mobilization of progenitor cells includes physical and pharmacological approaches, of which exercise and statin therapy have great potential. Angiogenesis is a pivotal defense mechanism to counteract hypoxia and is needed for plaque regression. However, neovessels are susceptible for intraplaque hemorrhage, particularly in diabetes mellitus. In these patients, the haptoglobin 2-2 genotype is the more affected, and may benefit from an antioxidant approach. Finally, the reverse cholesterol transport system is the main mechanism for plaque regression. In addition to high-density lipoprotein cholesterol, apolipoprotein A-I therapies and the promotion of cholesterol efflux from macrophages by the ABCA1 and ABCG1 transporter systems hold great promise and may be available for therapeutic application in the near future." @default.
- W1576231096 created "2016-06-24" @default.
- W1576231096 creator A5038592676 @default.
- W1576231096 creator A5063767504 @default.
- W1576231096 creator A5074727212 @default.
- W1576231096 date "2009-06-01" @default.
- W1576231096 modified "2023-09-30" @default.
- W1576231096 title "Promoting Mechanisms of Vascular Health" @default.
- W1576231096 cites W1516536249 @default.
- W1576231096 cites W1963772784 @default.
- W1576231096 cites W1966780233 @default.
- W1576231096 cites W1968196140 @default.
- W1576231096 cites W1971251695 @default.
- W1576231096 cites W1973355122 @default.
- W1576231096 cites W1976291192 @default.
- W1576231096 cites W1976431415 @default.
- W1576231096 cites W1976911481 @default.
- W1576231096 cites W1979080082 @default.
- W1576231096 cites W1980981003 @default.
- W1576231096 cites W1981192304 @default.
- W1576231096 cites W1983476670 @default.
- W1576231096 cites W1984236807 @default.
- W1576231096 cites W1987481001 @default.
- W1576231096 cites W1988448764 @default.
- W1576231096 cites W1989324706 @default.
- W1576231096 cites W1990231896 @default.
- W1576231096 cites W1991272474 @default.
- W1576231096 cites W1991332521 @default.
- W1576231096 cites W1992152105 @default.
- W1576231096 cites W1994953171 @default.
- W1576231096 cites W2002131026 @default.
- W1576231096 cites W2006227710 @default.
- W1576231096 cites W2010163367 @default.
- W1576231096 cites W2010417854 @default.
- W1576231096 cites W2011192430 @default.
- W1576231096 cites W2018299275 @default.
- W1576231096 cites W2023784586 @default.
- W1576231096 cites W2024455227 @default.
- W1576231096 cites W2026805430 @default.
- W1576231096 cites W2028103879 @default.
- W1576231096 cites W2031937052 @default.
- W1576231096 cites W2034966887 @default.
- W1576231096 cites W2036795046 @default.
- W1576231096 cites W2043685362 @default.
- W1576231096 cites W2044437167 @default.
- W1576231096 cites W2049052608 @default.
- W1576231096 cites W2049962129 @default.
- W1576231096 cites W2053704719 @default.
- W1576231096 cites W2055865829 @default.
- W1576231096 cites W2063301313 @default.
- W1576231096 cites W2069227574 @default.
- W1576231096 cites W2070999659 @default.
- W1576231096 cites W2071740677 @default.
- W1576231096 cites W2072754618 @default.
- W1576231096 cites W2074274911 @default.
- W1576231096 cites W2075087933 @default.
- W1576231096 cites W2075367810 @default.
- W1576231096 cites W2077214694 @default.
- W1576231096 cites W2078697224 @default.
- W1576231096 cites W2081366605 @default.
- W1576231096 cites W2084231836 @default.
- W1576231096 cites W2087772142 @default.
- W1576231096 cites W2090412876 @default.
- W1576231096 cites W2090492904 @default.
- W1576231096 cites W2091557419 @default.
- W1576231096 cites W2093296161 @default.
- W1576231096 cites W2094941678 @default.
- W1576231096 cites W2095160367 @default.
- W1576231096 cites W2095336654 @default.
- W1576231096 cites W2096061445 @default.
- W1576231096 cites W2099313535 @default.
- W1576231096 cites W2101406299 @default.
- W1576231096 cites W2104974272 @default.
- W1576231096 cites W2107175619 @default.
- W1576231096 cites W2108287070 @default.
- W1576231096 cites W2108928386 @default.
- W1576231096 cites W2111482014 @default.
- W1576231096 cites W2113504642 @default.
- W1576231096 cites W2115227919 @default.
- W1576231096 cites W2116708624 @default.
- W1576231096 cites W2122647205 @default.
- W1576231096 cites W2122673417 @default.
- W1576231096 cites W2122697183 @default.
- W1576231096 cites W2124091270 @default.
- W1576231096 cites W2125638994 @default.
- W1576231096 cites W2125757745 @default.
- W1576231096 cites W2127872440 @default.
- W1576231096 cites W2132418620 @default.
- W1576231096 cites W2137123183 @default.
- W1576231096 cites W2137161379 @default.
- W1576231096 cites W2139836755 @default.
- W1576231096 cites W2140402044 @default.
- W1576231096 cites W2142041241 @default.
- W1576231096 cites W2144694419 @default.
- W1576231096 cites W2144739178 @default.
- W1576231096 cites W2144988746 @default.
- W1576231096 cites W2148609678 @default.
- W1576231096 cites W2152982842 @default.