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• W1576360491 abstract "Frequency of neurodegenerative diseases increase significantly with the age. One of the most frightening and devastating of all neurological disorders is the dementia that occurs in the elderly. Dementia is a common name for progressive degenerative brain syndromes which affect memory, thinking, behaviour and emotions. Dementia mainly affects older people, although there is a growing incidence of the cases that start before the age of 65. After age 65, the likelihood of developing dementia roughly doubles every five years. Dementia affects 1 – 6% of human population over 65 years and 10 – 20% over 80 years. In the present, average age is increasing and the number of people over 60 years increases as well. Although Ageing is a physiological process, however it seems to be linked with an increasing risk of origin and development of several diseases including neurodegenerative disorders. Dementia is characterised by the loss of or decline in memory and other cognitive abilities. It is caused by various diseases and conditions resulting in damaging brain cells. Different types of dementia (Alzheimer`s disease, vascular dementia or post-stroke dementia, mixed dementia, dementia with Lewy bodies, Parkinson`s disease, frontotemporal dementia, Creutzfeld-Jacob disease, normal pressure hydrocephalus) have been associated with distinct symptom patterns and distinguishing microscopic brain abnormalities. Alzheimer's disease (AD) is the most common cause of dementia and this disease represents 60 – 80% of all dementia. Alzheimer's disease is age-related disease and it is characterized by a range of changes in brain anatomy, biochemistry, genetic, and function. According to Alzheimer`s disease International in 2010, there were an estimated 35.6 million people with dementia worldwide. This means a 10 percent increase over previous global dementia prevalence reported in 2005 in The Lancet. Number of people with dementia will be increasing to 65.7 million by 2030 and 115.4 million by 2050. Hallmark abnormalities of Alzheimer`s disease are deposits of the protein fragment ┚-amyloid (plaques) and twisted strands of the protein tau (tangles). Protein oxidation and generation of protein aggregates may be caused by loss of cell function alike a decreased ability of old organisms to resist the physiological stresses and oxidative damage. The relationship between protein aggregation, oxidative damage and neurodegenerative" @default.
• W1576360491 created "2016-06-24" @default.
• W1576360491 creator A5018543953 @default.
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• W1576360491 creator A5076624039 @default.
• W1576360491 date "2011-12-16" @default.
• W1576360491 modified "2023-10-16" @default.
• W1576360491 title "Alzheimer's Disease: Definition, Molecular and Genetic Factors" @default.
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