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- W1576492606 abstract "Protein-related homocysteine (Hcy) metabolism produces Hcy-thiolactone, N-Hcy-protein, and N epsilon-homocysteinyl-lysine (N epsilon-Hcy-Lys). Hcy-thiolactone is generated in an error-editing reaction in protein biosynthesis when Hcy is erroneously selected in place of methionine by methionyl-tRNA synthetase. Hcy-thiolactone, an intramolecular thioester, is chemically reactive and forms isopeptide bonds with protein lysine residues in a process called N-homocysteinylation, which impairs or alters the protein's biological function. The resulting protein damage is exacerbated by a thiyl radical-mediated oxidation. N-Hcy-proteins undergo structural changes leading to aggregation and amyloid formation. These structural changes generate proteins, which are toxic and which induce an autoimmune response. Proteolytic degradation of N-Hcy-proteins generates N epsilon-Hcy-Lys. Levels of Hcy-thiolactone, N-Hcy-protein, and N epsilon-Hcy-Lys increase under pathological conditions in humans and mice and have been linked to cardiovascular and brain disorders. This chapter reviews fundamental biological chemistry of Hcy-thiolactone, N-Hcy-protein, and N epsilon-Hcy-Lys and discusses their clinical significance." @default.
- W1576492606 created "2016-06-24" @default.
- W1576492606 creator A5044158677 @default.
- W1576492606 creator A5062502288 @default.
- W1576492606 date "2011-01-01" @default.
- W1576492606 modified "2023-10-18" @default.
- W1576492606 title "Chemical Biology of Homocysteine Thiolactone and Related Metabolites" @default.
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- W1576492606 doi "https://doi.org/10.1016/b978-0-12-387042-1.00005-8" @default.
- W1576492606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22126025" @default.
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