FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1576553411> ?p ?o ?g. }

• W1576553411 abstract "The high-affinity degradation of low-density lipoprotein (LDL) is enhanced 3- to 100-fold in leukemic blood cells from patients with acute myelogenous leukemia (AML), suggesting an increased cellular LDL receptor expression. There are, however, inconsistencies regarding the published properties of LDL receptor regulation in AML cells, and previous data on this are indirect. In the present study the aim was to determine whether the LDL receptor number is increased in AML cells. The LDL receptor number was assayed by ligand blot with rabbit 125I-labeled beta-very-low-density lipoprotein (beta-VLDL) of transferred, SDS-polyacrylamide-gel-electrophoresis-separated AML cell membranes. Samples from 10 patients, six with AML, one with chronic myelogenous leukemia in blast crisis, and three with acute lymphoblastic leukemia, were investigated. The LDL receptor expression was strongly suppressed in all samples to levels lower than that of normal mononuclear cells. This was despite the fact that cells from one patient with AML of M4 subtype had a 50- to 100-fold higher 125I labeled LDL degradation compared with normal cells. Immunoblots with antibodies against gp330/megalin and the LDL-receptor-related protein (LRP) and ligand blot using 125I-labeled 39-kd receptor-associated protein (RAP) could not detect gp330/megalin or VLDL receptors. The LRP was abundant in AML samples of M4 and M5b subtype, as determined from both RAP ligand blot and immunoblot using an LRP-specific antibody. It is concluded that LDL receptors are suppressed in AML cells. It is possible that the high degradation of 125I-labeled LDL present in type M4 and M5 AML cells may involve another lipoprotein receptor." @default.
• W1576553411 created "2016-06-24" @default.
• W1576553411 creator A5035143175 @default.
• W1576553411 creator A5054816073 @default.
• W1576553411 creator A5060250865 @default.
• W1576553411 creator A5066284854 @default.
• W1576553411 creator A5087634388 @default.
• W1576553411 date "1998-12-01" @default.
• W1576553411 modified "2023-10-02" @default.
• W1576553411 title "Lipoprotein Receptors in Acute Myelogenous Leukemia" @default.
• W1576553411 cites W1485806819 @default.
• W1576553411 cites W1490629978 @default.
• W1576553411 cites W1495390974 @default.
• W1576553411 cites W152075184 @default.
• W1576553411 cites W1527704744 @default.
• W1576553411 cites W1539895365 @default.
• W1576553411 cites W1775749144 @default.
• W1576553411 cites W195935352 @default.
• W1576553411 cites W1966954313 @default.
• W1576553411 cites W1978541544 @default.
• W1576553411 cites W1981802108 @default.
• W1576553411 cites W1988446669 @default.
• W1576553411 cites W1995618009 @default.
• W1576553411 cites W1998600489 @default.
• W1576553411 cites W2002700276 @default.
• W1576553411 cites W2005922438 @default.
• W1576553411 cites W2010715617 @default.
• W1576553411 cites W2018289835 @default.
• W1576553411 cites W2022630419 @default.
• W1576553411 cites W2028597436 @default.
• W1576553411 cites W2029144810 @default.
• W1576553411 cites W2030661043 @default.
• W1576553411 cites W2055464067 @default.
• W1576553411 cites W2071124826 @default.
• W1576553411 cites W2072893670 @default.
• W1576553411 cites W2074591785 @default.
• W1576553411 cites W2075408197 @default.
• W1576553411 cites W2076426515 @default.
• W1576553411 cites W2077576735 @default.
• W1576553411 cites W2081860696 @default.
• W1576553411 cites W2084744450 @default.
• W1576553411 cites W2085645594 @default.
• W1576553411 cites W2088132089 @default.
• W1576553411 cites W2090777746 @default.
• W1576553411 cites W2094325605 @default.
• W1576553411 cites W2096542871 @default.
• W1576553411 cites W2100837269 @default.
• W1576553411 cites W2111817213 @default.
• W1576553411 cites W2128635872 @default.
• W1576553411 cites W2129205716 @default.
• W1576553411 cites W2135503869 @default.
• W1576553411 cites W2147365254 @default.
• W1576553411 cites W2155759352 @default.
• W1576553411 cites W2156153564 @default.
• W1576553411 cites W2182936926 @default.
• W1576553411 cites W2187046247 @default.
• W1576553411 cites W2279344163 @default.
• W1576553411 cites W2341279355 @default.
• W1576553411 cites W2404445223 @default.
• W1576553411 cites W4255440954 @default.
• W1576553411 cites W4293247451 @default.
• W1576553411 doi "https://doi.org/10.1016/s0002-9440(10)65706-9" @default.
• W1576553411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1866319" @default.
• W1576553411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9846982" @default.
• W1576553411 hasPublicationYear "1998" @default.
• W1576553411 type Work @default.
• W1576553411 sameAs 1576553411 @default.
• W1576553411 citedByCount "23" @default.
• W1576553411 countsByYear W15765534112013 @default.
• W1576553411 countsByYear W15765534112014 @default.
• W1576553411 countsByYear W15765534112015 @default.
• W1576553411 countsByYear W15765534112016 @default.
• W1576553411 countsByYear W15765534112017 @default.
• W1576553411 countsByYear W15765534112021 @default.
• W1576553411 crossrefType "journal-article" @default.
• W1576553411 hasAuthorship W1576553411A5035143175 @default.
• W1576553411 hasAuthorship W1576553411A5054816073 @default.
• W1576553411 hasAuthorship W1576553411A5060250865 @default.
• W1576553411 hasAuthorship W1576553411A5066284854 @default.
• W1576553411 hasAuthorship W1576553411A5087634388 @default.
• W1576553411 hasBestOaLocation W15765534112 @default.
• W1576553411 hasConcept C104317684 @default.
• W1576553411 hasConcept C134018914 @default.
• W1576553411 hasConcept C137061746 @default.
• W1576553411 hasConcept C153911025 @default.
• W1576553411 hasConcept C159654299 @default.
• W1576553411 hasConcept C170493617 @default.
• W1576553411 hasConcept C185592680 @default.
• W1576553411 hasConcept C202751555 @default.
• W1576553411 hasConcept C203014093 @default.
• W1576553411 hasConcept C2776415932 @default.
• W1576553411 hasConcept C2776960273 @default.
• W1576553411 hasConcept C2778163477 @default.
• W1576553411 hasConcept C2778461978 @default.
• W1576553411 hasConcept C2779620165 @default.
• W1576553411 hasConcept C2780072125 @default.
• W1576553411 hasConcept C43554185 @default.
• W1576553411 hasConcept C55493867 @default.
• W1576553411 hasConcept C86803240 @default.
• W1576553411 hasConceptScore W1576553411C104317684 @default.

• next