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- W1576571210 endingPage "112" @default.
- W1576571210 startingPage "84" @default.
- W1576571210 abstract "Summary: Defensins are small, multifunctional cationic peptides. They typically contain six conserved cysteines whose three intramolecular disulfides stabilize a largely β-sheet structure. This review of human α-defensins begins by describing their evolution, including their likely relationship to the Big Defensins of invertebrates, and their kinship to the β-defensin peptides of many if not all vertebrates, and the θ-defensins found in certain non-human primates. We provide a short history of the search for leukocyte-derived microbicidal molecules, emphasizing the roles played by luck (good), preconceived notions (mostly bad), and proper timing (essential). The antimicrobial, antiviral, antitoxic, and binding properties of human α-defensins are summarized. The structural features of α-defensins are described extensively and their functional contributions are assessed. The properties of HD6, an enigmatic Paneth cell α-defensin, are contrasted with those of the four myeloid α-defensins (HNP1–4) and of HD5, the other α-defensin of human Paneth cells. The review ends with a decalogue that may assist researchers or students interested in α-defensins and related aspects of neutrophil function." @default.
- W1576571210 created "2016-06-24" @default.
- W1576571210 creator A5058806039 @default.
- W1576571210 creator A5068243367 @default.
- W1576571210 date "2011-12-15" @default.
- W1576571210 modified "2023-10-13" @default.
- W1576571210 title "α-Defensins in human innate immunity" @default.
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