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• W1576585516 abstract "The acute phase (AP) response to infection decreases appetite and alters markers of micronutrient status. The effect of febrile malaria on dietary intake was determined using data from a 3-mo controlled feeding trial in Zambian children (n = 181, 3-5 y). Lower intakes were observed for all variables during malaria (food 289 ± 412 g; energy 248 ± 346 kcal; carbohydrate 42 ± 62 g; protein 8 ± 12 g; fat 5 ± 7 g; iron 1 ± 2 mg; zinc 1 ± 1 mg; vitamin A [VA] 58 ± 100 retinol activity equivalents; all P < 0.05). The impact of infection on VA and iron markers was elucidated with baseline (B) and final (F) bloods. Early, mid, and convalescing stages of infection were identified with the respective categories of AP proteins: raised C-reactive protein (CRP > 5 mg/L or > 10 mg/L) only, raised CRP and α1-acid glycoprotein (AGP > 1.2 g/L), and raised AGP only. Hemoglobin (Hb) decreased (14–15% at B; 11 – 16% at F; P < 0.05), plasma ferritin (PF) increased (359–356% at B; 279–353% at F; P < 0.05), serum retinol (SR) decreased (21% at B with CRP> 5 mg/L; 30–33% at F; P < 0.05), and MRDR score was unaffected (P > 0.05) during mid-infection. Hb, SR, and MRDR did not change during convalescence; however, PF remained increased (67–84% at B; 157% at F with CRP >10 mg/L; P < 0.05). Patterns of significance were similar when using either CRP > 5 mg/L or > 10 mg/L as the raised cut-off point. More research is needed to examine early infection. It is important to consider the impact of infection on dietary interventions and to adjust for AP proteins when assessing iron status or VA status by serum retinol in children." @default.
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• W1576585516 date "2014-04-01" @default.
• W1576585516 modified "2023-09-26" @default.
• W1576585516 title "Acute phase response is associated with decreased nutrient intake and altered markers of micronutrient status in Zambian children (624.16)" @default.
• W1576585516 doi "https://doi.org/10.1096/fasebj.28.1_supplement.624.16" @default.
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