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• W1576598049 abstract "Abstract Lantibiotics are a unique class of antimicrobial peptides produced by Gram‐positive bacteria. They are synthesized ribosomally as precursor peptides and undergo extensive posttranslational modification to attain their biologically active structures. These modifications include dehydration of serine and threonine residues that produce dehydroalanines and dehydrobutyrines, followed by intramolecular addition of cysteine thiols to the unsaturated amino acids. The lantibiotic biosynthetic machinery displays low substrate specificity both in vivo and in vitro , which allows for the engineering of novel lantibiotics. The polycyclic peptides exert their biological activity through several modes of action including the sequestration of the cell wall precursor lipid II and pore formation in bacterial membranes. Because of their high potency, several commercial applications of lantibiotics are being developed." @default.
• W1576598049 created "2016-06-24" @default.
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• W1576598049 date "2008-05-15" @default.
• W1576598049 modified "2023-10-10" @default.
• W1576598049 title "Lantibiotics: Biosynthesis and Modes of Action" @default.
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• W1576598049 doi "https://doi.org/10.1002/9780470048672.wecb277" @default.
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