Matches in SemOpenAlex for { <https://semopenalex.org/work/W1576698873> ?p ?o ?g. }
- W1576698873 endingPage "54" @default.
- W1576698873 startingPage "330" @default.
- W1576698873 abstract "This article examines associations between gluten, polymorphisms of the major histocompatibility complex, and mucosal pathology representative of the spectrum of gluten sensitivity. Sequences of wheat, rye, and barley prolamins contain recurring tetrapeptide motifs that are predicted to have beta-reverse-turn secondary structure and that, with in vitro assays, appear active. Structural polymorphisms of major histocompatibility complex subloci identify codon switches within the second exon that control the third hypervariable region in the outer domain of the beta chain. Observations of the intestinal response to gluten reveal five interrelated lesions (preinfiltrative, infiltrative, hyperplastic, destructive, and hypoplastic) that are interpretable as cell-mediated immunologic responses. These responses originate in the lamina propria, where a series of antigen-specific inflammatory processes has now been identified. There is no evidence that celiac sprue is a disease of jejunal enterocytes. Furthermore, the role of intraepithelial space lymphocytes in pathogenesis, if relevant, needs further experimental dissection. Also awaiting further definition are polymorphisms of the celiac lymphocyte antigen receptor and their relationship to gliadin oligopeptide(s) and predisposing genes. The nature and basis of nonresponsive celiac sprue require more thoughtful initiatives to elucidate the immunologic mechanism(s) of unresponsiveness and evaluate possible means of reversal. Finally, a more sensible definition of gluten sensitivity (unhampered by qualitative morphological imagery) is ultimately called for in order to accommodate the biomolecular advances addressed in this review." @default.
- W1576698873 created "2016-06-24" @default.
- W1576698873 creator A5079145065 @default.
- W1576698873 date "1992-01-01" @default.
- W1576698873 modified "2023-10-17" @default.
- W1576698873 title "Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity ('celiac sprue')." @default.
- W1576698873 cites W138445230 @default.
- W1576698873 cites W1421318040 @default.
- W1576698873 cites W1458199493 @default.
- W1576698873 cites W1464429710 @default.
- W1576698873 cites W1533027986 @default.
- W1576698873 cites W153972386 @default.
- W1576698873 cites W1546359438 @default.
- W1576698873 cites W1546766336 @default.
- W1576698873 cites W1548101699 @default.
- W1576698873 cites W1555869406 @default.
- W1576698873 cites W1556648663 @default.
- W1576698873 cites W1560443971 @default.
- W1576698873 cites W1562547014 @default.
- W1576698873 cites W1563685788 @default.
- W1576698873 cites W1567859163 @default.
- W1576698873 cites W1570572164 @default.
- W1576698873 cites W1593162005 @default.
- W1576698873 cites W1593389519 @default.
- W1576698873 cites W1595389491 @default.
- W1576698873 cites W1599841966 @default.
- W1576698873 cites W160018558 @default.
- W1576698873 cites W1607621565 @default.
- W1576698873 cites W1630713488 @default.
- W1576698873 cites W1635281797 @default.
- W1576698873 cites W1653603848 @default.
- W1576698873 cites W1680267005 @default.
- W1576698873 cites W1749490496 @default.
- W1576698873 cites W17537174 @default.
- W1576698873 cites W1820347146 @default.
- W1576698873 cites W1853022482 @default.
- W1576698873 cites W1857680470 @default.
- W1576698873 cites W1890778088 @default.
- W1576698873 cites W1907390245 @default.
- W1576698873 cites W1912320407 @default.
- W1576698873 cites W1921962230 @default.
- W1576698873 cites W1928348093 @default.
- W1576698873 cites W1939182017 @default.
- W1576698873 cites W1939611527 @default.
- W1576698873 cites W1963632040 @default.
- W1576698873 cites W1964044302 @default.
- W1576698873 cites W1965082041 @default.
- W1576698873 cites W1965790872 @default.
- W1576698873 cites W1966590326 @default.
- W1576698873 cites W1966862024 @default.
- W1576698873 cites W1967683455 @default.
- W1576698873 cites W1969668781 @default.
- W1576698873 cites W1969753101 @default.
- W1576698873 cites W1971045184 @default.
- W1576698873 cites W1971424659 @default.
- W1576698873 cites W1972203393 @default.
- W1576698873 cites W1976094538 @default.
- W1576698873 cites W1980514031 @default.
- W1576698873 cites W1980655393 @default.
- W1576698873 cites W1980699774 @default.
- W1576698873 cites W1982132444 @default.
- W1576698873 cites W1982142248 @default.
- W1576698873 cites W1983459630 @default.
- W1576698873 cites W1983563924 @default.
- W1576698873 cites W1985443814 @default.
- W1576698873 cites W1986333783 @default.
- W1576698873 cites W1987053128 @default.
- W1576698873 cites W1987793228 @default.
- W1576698873 cites W1989996602 @default.
- W1576698873 cites W1990319518 @default.
- W1576698873 cites W1990320730 @default.
- W1576698873 cites W1990533631 @default.
- W1576698873 cites W1993045121 @default.
- W1576698873 cites W1993649554 @default.
- W1576698873 cites W1993954534 @default.
- W1576698873 cites W1995934713 @default.
- W1576698873 cites W1998531275 @default.
- W1576698873 cites W2001464509 @default.
- W1576698873 cites W2001615328 @default.
- W1576698873 cites W2007051027 @default.
- W1576698873 cites W2010336953 @default.
- W1576698873 cites W2010892339 @default.
- W1576698873 cites W2012546308 @default.
- W1576698873 cites W2012716149 @default.
- W1576698873 cites W2013649386 @default.
- W1576698873 cites W2015905633 @default.
- W1576698873 cites W2016619484 @default.
- W1576698873 cites W2017153941 @default.
- W1576698873 cites W2017690805 @default.
- W1576698873 cites W2018132211 @default.
- W1576698873 cites W2018334984 @default.
- W1576698873 cites W2018435845 @default.
- W1576698873 cites W2019536090 @default.
- W1576698873 cites W2022001640 @default.
- W1576698873 cites W2023588806 @default.
- W1576698873 cites W2024634401 @default.
- W1576698873 cites W2025079235 @default.
- W1576698873 cites W2025270507 @default.