FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1576796078> ?p ?o ?g. }

• W1576796078 abstract "In malaria endemic regions a fetus is often exposed in utero to Plasmodium falciparum (Pf) blood stage antigens. In some newborns this can result in the induction of immune suppression which subsequently can increase a child´s susceptibility to infection. To test the hypothesis that this immune suppression is partially mediated by malaria-specific T-regulatory cells in utero, cord blood mononuclear cells (CBMC) were obtained from 44 Kenyan newborns of women with and without malaria at delivery. CD4+CD25lo T cells and CD4+CD25hi FoxP3+ cells (Treg) were enriched from CBMC. Treg cell frequency and HLA-DR expression on Tregs were significantly greater for Kenyan as compared to North American CBMC (p<0.01). CBMC/CD4+T cells cultured with Pf blood antigens induced production of IFNγ, IL-13, IL-10, and/or IL-5 in 50% of samples. Partial depletion of CD25hi cells augmented the antigen-driven IFNγ production in 69% of subjects with malaria-specific responses and revealed additional antigen reactive lymphocytes in previously unresponsive individuals (n=3). Addition of Tregs to CD4+CD25lo cells suppressed spontaneous and malaria antigen-driven production of IFNγ in a dose-dependent fashion, until production was completely inhibited in most subjects. In contrast, Tregs only partially suppressed malaria induced Th2 cytokines. IL-10 or TGFβ did not mediate this suppression. Thus, prenatal exposure to malaria blood stage antigens induces Treg cells that primarily suppress Th1- type recall responses to Pf blood-stage antigens. Persistence of these regulatory T cells postnatally could modify a child’s susceptibility to malaria infection and disease. In Malaria-endemischen Regionen kann bereits in utero eine Exposition von Foten mit Malariaantigenen erfolgen. Bei einigen Neugeborenen fuhrt dies zu einer supprimierten Immunantwort zu Malaria, welche persistieren und spater die Infektionsanfalligkeit erhohen kann. Um die Hypothese zu uberprufen, das diese beobachtete Immunsuppression teilweise durch regulatorische T-Zellen induziert wird, haben wir mononukleare Zellen aus Nabelschnurblut von 44 Frauen in Kenya untersucht. Wir konnten zeigen, das die Zahl an CD4+CD25+FOXP3+ regulatorischen T-Zellen sowie die HLA-DR Expression von regulatorischen T-Zellen bei Neugeborenen von kenyanischen Frauen signifikant groser war als von nordamerikanischen Frauen. In 50% der Neugeborenen konnten wir eine malaria-antigen-spezifische Zytokinantwort in CD4+- Zellkulturen nachweisen (IFNγ, IL-13, IL-10, und/oder IL-5). Nach Zugabe von regulatorischen T-Zellen zu den Zellkulturen wurde die antigen-spezifische IFNγ Antwort fast vollstandig supprimiert. Die Suppression von TH2-Zytokinen war weniger ausgepragt. Die beobachtete Suppression erfolgte unabhangig von IL10 oder TGFβ. Zusammenfassend kann man sagen, das durch pranatale Exposition zu Malariaantigenen regulatorische T-Zellen induziert werden, die insbesondere die TH1-Immunantwort zu Malariaantigenen supprimieren. Ein Persistieren dieser regulatorischen T-Zellen konnte spater im Kindesalter die Immunantwort zu Malaria beeinflussen und zu einer erhohten Anfalligkeit fur Malariainfektionen fuhren." @default.
• W1576796078 created "2016-06-24" @default.
• W1576796078 creator A5005633778 @default.
• W1576796078 date "2012-09-18" @default.
• W1576796078 modified "2023-09-24" @default.
• W1576796078 title "The prenatally acquired T cell response to Plasmodium falciparum malaria and the role of regulatory T cells" @default.
• W1576796078 cites W1485653263 @default.
• W1576796078 cites W1508527175 @default.
• W1576796078 cites W1529708509 @default.
• W1576796078 cites W1541333106 @default.
• W1576796078 cites W1560277370 @default.
• W1576796078 cites W1562008267 @default.
• W1576796078 cites W1574663960 @default.
• W1576796078 cites W1586538320 @default.
• W1576796078 cites W1590965838 @default.
• W1576796078 cites W1655136182 @default.
• W1576796078 cites W1660800855 @default.
• W1576796078 cites W1785427672 @default.
• W1576796078 cites W1893220347 @default.
• W1576796078 cites W1918136402 @default.
• W1576796078 cites W1966968265 @default.
• W1576796078 cites W1969200707 @default.
• W1576796078 cites W1972455890 @default.
• W1576796078 cites W1979049274 @default.
• W1576796078 cites W1981355586 @default.
• W1576796078 cites W1982126960 @default.
• W1576796078 cites W1984909066 @default.
• W1576796078 cites W1986477512 @default.
• W1576796078 cites W1989760839 @default.
• W1576796078 cites W1998858806 @default.
• W1576796078 cites W2000587047 @default.
• W1576796078 cites W2005689995 @default.
• W1576796078 cites W2008900005 @default.
• W1576796078 cites W2012973954 @default.
• W1576796078 cites W2020151812 @default.
• W1576796078 cites W2026628287 @default.
• W1576796078 cites W2026836824 @default.
• W1576796078 cites W2027729283 @default.
• W1576796078 cites W2032147470 @default.
• W1576796078 cites W2032372422 @default.
• W1576796078 cites W2033330275 @default.
• W1576796078 cites W2037780312 @default.
• W1576796078 cites W2044035130 @default.
• W1576796078 cites W2044099206 @default.
• W1576796078 cites W2059371769 @default.
• W1576796078 cites W2061985630 @default.
• W1576796078 cites W2062794407 @default.
• W1576796078 cites W2067648924 @default.
• W1576796078 cites W2068886516 @default.
• W1576796078 cites W2069890225 @default.
• W1576796078 cites W2072066004 @default.
• W1576796078 cites W2073694191 @default.
• W1576796078 cites W2076000327 @default.
• W1576796078 cites W2076003344 @default.
• W1576796078 cites W2076120131 @default.
• W1576796078 cites W2082103019 @default.
• W1576796078 cites W2092365405 @default.
• W1576796078 cites W2096954984 @default.
• W1576796078 cites W2098970896 @default.
• W1576796078 cites W2099865725 @default.
• W1576796078 cites W2112506009 @default.
• W1576796078 cites W2115489900 @default.
• W1576796078 cites W2119534447 @default.
• W1576796078 cites W2120444734 @default.
• W1576796078 cites W2138961639 @default.
• W1576796078 cites W2139019810 @default.
• W1576796078 cites W2140032559 @default.
• W1576796078 cites W2142734924 @default.
• W1576796078 cites W2143514176 @default.
• W1576796078 cites W2143631009 @default.
• W1576796078 cites W2148245227 @default.
• W1576796078 cites W2149626878 @default.
• W1576796078 cites W2150567785 @default.
• W1576796078 cites W2153389047 @default.
• W1576796078 cites W2154459215 @default.
• W1576796078 cites W2156964052 @default.
• W1576796078 cites W2160559960 @default.
• W1576796078 cites W2162336293 @default.
• W1576796078 cites W2163592077 @default.
• W1576796078 cites W2167406706 @default.
• W1576796078 cites W2168079915 @default.
• W1576796078 cites W2168448634 @default.
• W1576796078 cites W2168628806 @default.
• W1576796078 cites W2168652259 @default.
• W1576796078 cites W2199979178 @default.
• W1576796078 cites W2256537345 @default.
• W1576796078 cites W2160882943 @default.
• W1576796078 hasPublicationYear "2012" @default.
• W1576796078 type Work @default.
• W1576796078 sameAs 1576796078 @default.
• W1576796078 citedByCount "0" @default.
• W1576796078 crossrefType "journal-article" @default.
• W1576796078 hasAuthorship W1576796078A5005633778 @default.
• W1576796078 hasConcept C137061746 @default.
• W1576796078 hasConcept C147483822 @default.
• W1576796078 hasConcept C202751555 @default.
• W1576796078 hasConcept C203014093 @default.
• W1576796078 hasConcept C2776090121 @default.
• W1576796078 hasConcept C2778048844 @default.
• W1576796078 hasConcept C2779727006 @default.

• next