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- W1576960005 abstract "Publisher Summary It is the current view that gap junctions are not only passive conduits of electrical charge but also dynamic filters that modulate the passage of molecular messages within the cellular network; hence, not only the presence but also the regulation of connexins is important for synchronous tissue function. Research has focused on the regulation of connexins by two separate factors: intracellular pH and insulin (or IGF) exposure. Regulation of gap junction conductance by factors such as pH i and cytokines may be critical in the development of lethal cardiac arrhythmias during ischemia. Growth factor-mediated regulation of intercellular communication may also be important for normal cardiogenesis. Finally, changes in pH sensitivity after connexin processing may allow the preservation of cell–cell communication in the lens. Understanding the molecular events controlling connexin regulation and developing means to manipulate their occurrence allow learning more about the importance of intercellular communication both in health and disease." @default.
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- W1576960005 date "1999-01-01" @default.
- W1576960005 modified "2023-10-18" @default.
- W1576960005 title "Chapter 11: A Molecular Model for the Chemical Regulation of Connexin43 Channels: The “Ball-and-Chain” Hypothesis" @default.
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- W1576960005 doi "https://doi.org/10.1016/s0070-2161(08)61015-1" @default.
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