FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1577102179> ?p ?o ?g. }

• W1577102179 endingPage "666" @default.
• W1577102179 startingPage "658" @default.
• W1577102179 abstract "Propofol concentrations that produce laboratory-based cardioprotective effects are generally greater than those produced under routine anesthesia during cardiac surgery. It is unknown whether experimental cardioprotective propofol concentrations can routinely be achieved during cardiopulmonary bypass (CPB) using continuous infusion. Twenty-four patients scheduled for primary aortocoronary bypass grafting with CPB were allocated to receive one of three propofol infusion rates; 50, 100, or 150 μg · kg−1 · min−1 in an open-label pilot study. Data were described using a line of best fit to derive an experimental clinical maneuver predicted to produce a whole blood concentration of 5 μg · mL−1 at reperfusion. A predetermined interim analysis of 30 patients who were receiving the derived maneuver in an ongoing study was used to evaluate the maneuver. Cardiac index (CI), systemic vascular resistance index (SVRI), and left ventricular stroke work index (LVSWI) were recorded. The infusion rate-concentration curve had an equation of y = 0.215e 0.0279x , where y represents the whole blood concentration and x represents the infusion rate (r 2 = 0.781). The predicted infusion rate to achieve a mean concentration of 5 μg · mL−1 was 113 μg · kg−1 · min−1. The nearest practical rate is 120 μg · kg−1 · min−1, producing a concentration of 5.39 (1.45) μg · mL−1. The values for CI, SVRI, and LVSWI were similar between groups at corresponding time periods. An infusion rate of 120 μg · kg−1 · min−1 is clinically practical and capable of achieving experimental cardioprotective propofol concentrations at reperfusion." @default.
• W1577102179 created "2016-06-24" @default.
• W1577102179 creator A5016611685 @default.
• W1577102179 creator A5027435358 @default.
• W1577102179 creator A5030083769 @default.
• W1577102179 creator A5031445127 @default.
• W1577102179 creator A5031936876 @default.
• W1577102179 creator A5046692971 @default.
• W1577102179 creator A5069849278 @default.
• W1577102179 date "2009-07-29" @default.
• W1577102179 modified "2023-10-16" @default.
• W1577102179 title "Target-achieved propofol concentration during on-pump cardiac surgery: a pilot dose-finding study" @default.
• W1577102179 cites W1525310058 @default.
• W1577102179 cites W1619748853 @default.
• W1577102179 cites W1812132249 @default.
• W1577102179 cites W196056030 @default.
• W1577102179 cites W1965169538 @default.
• W1577102179 cites W1965870838 @default.
• W1577102179 cites W1976048411 @default.
• W1577102179 cites W1987636628 @default.
• W1577102179 cites W1990483240 @default.
• W1577102179 cites W1994481989 @default.
• W1577102179 cites W1995576508 @default.
• W1577102179 cites W2004154230 @default.
• W1577102179 cites W2007402693 @default.
• W1577102179 cites W2010422175 @default.
• W1577102179 cites W2031670338 @default.
• W1577102179 cites W2035366895 @default.
• W1577102179 cites W2041941023 @default.
• W1577102179 cites W2045157717 @default.
• W1577102179 cites W2045719846 @default.
• W1577102179 cites W2054742735 @default.
• W1577102179 cites W2060106528 @default.
• W1577102179 cites W2060357972 @default.
• W1577102179 cites W2063074191 @default.
• W1577102179 cites W2063673182 @default.
• W1577102179 cites W2066334661 @default.
• W1577102179 cites W2070469839 @default.
• W1577102179 cites W2073392634 @default.
• W1577102179 cites W2077463963 @default.
• W1577102179 cites W2084943479 @default.
• W1577102179 cites W2097777146 @default.
• W1577102179 cites W2100760558 @default.
• W1577102179 cites W2118961159 @default.
• W1577102179 cites W2118983973 @default.
• W1577102179 cites W2126183514 @default.
• W1577102179 cites W2134325937 @default.
• W1577102179 cites W2142147247 @default.
• W1577102179 cites W2148497928 @default.
• W1577102179 cites W2160821564 @default.
• W1577102179 cites W2166700156 @default.
• W1577102179 cites W2171369070 @default.
• W1577102179 cites W2172267225 @default.
• W1577102179 cites W2410355819 @default.
• W1577102179 cites W4235211183 @default.
• W1577102179 doi "https://doi.org/10.1007/s12630-009-9145-3" @default.
• W1577102179 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19639375" @default.
• W1577102179 hasPublicationYear "2009" @default.
• W1577102179 type Work @default.
• W1577102179 sameAs 1577102179 @default.
• W1577102179 citedByCount "6" @default.
• W1577102179 countsByYear W15771021792012 @default.
• W1577102179 countsByYear W15771021792014 @default.
• W1577102179 countsByYear W15771021792015 @default.
• W1577102179 crossrefType "journal-article" @default.
• W1577102179 hasAuthorship W1577102179A5016611685 @default.
• W1577102179 hasAuthorship W1577102179A5027435358 @default.
• W1577102179 hasAuthorship W1577102179A5030083769 @default.
• W1577102179 hasAuthorship W1577102179A5031445127 @default.
• W1577102179 hasAuthorship W1577102179A5031936876 @default.
• W1577102179 hasAuthorship W1577102179A5046692971 @default.
• W1577102179 hasAuthorship W1577102179A5069849278 @default.
• W1577102179 hasBestOaLocation W15771021791 @default.
• W1577102179 hasConcept C126322002 @default.
• W1577102179 hasConcept C139940330 @default.
• W1577102179 hasConcept C164705383 @default.
• W1577102179 hasConcept C178853913 @default.
• W1577102179 hasConcept C2776277131 @default.
• W1577102179 hasConcept C2777953023 @default.
• W1577102179 hasConcept C2778789114 @default.
• W1577102179 hasConcept C2778881276 @default.
• W1577102179 hasConcept C31861589 @default.
• W1577102179 hasConcept C35294091 @default.
• W1577102179 hasConcept C42219234 @default.
• W1577102179 hasConcept C58245268 @default.
• W1577102179 hasConcept C71924100 @default.
• W1577102179 hasConcept C80461066 @default.
• W1577102179 hasConcept C84393581 @default.
• W1577102179 hasConceptScore W1577102179C126322002 @default.
• W1577102179 hasConceptScore W1577102179C139940330 @default.
• W1577102179 hasConceptScore W1577102179C164705383 @default.
• W1577102179 hasConceptScore W1577102179C178853913 @default.
• W1577102179 hasConceptScore W1577102179C2776277131 @default.
• W1577102179 hasConceptScore W1577102179C2777953023 @default.
• W1577102179 hasConceptScore W1577102179C2778789114 @default.
• W1577102179 hasConceptScore W1577102179C2778881276 @default.
• W1577102179 hasConceptScore W1577102179C31861589 @default.
• W1577102179 hasConceptScore W1577102179C35294091 @default.

• next