Matches in SemOpenAlex for { <https://semopenalex.org/work/W1577173685> ?p ?o ?g. }
- W1577173685 endingPage "3597" @default.
- W1577173685 startingPage "3582" @default.
- W1577173685 abstract "While neurovascular diseases such as ischemic and hemorrhagic stroke are the leading causes of disability in the world, the repertoire of therapeutic interventions has remained remarkably limited. There is a dire need to develop new diagnostic, prognostic, and therapeutic options. The study of proteomics is particularly enticing for cerebrovascular diseases such as stroke, which most likely involve multiple gene interactions resulting in a wide range of clinical phenotypes. Currently, rapidly progressing neuroproteomic techniques have been employed in clinical and translational research to help identify biologically relevant pathways, to understand cerebrovascular pathophysiology, and to develop novel therapeutics and diagnostics. Future integration of proteomic with genomic, transcriptomic, and metabolomic studies will add new perspectives to better understand the complexities of neurovascular injury. Here, we review cerebrovascular proteomics research in both preclinical (animal, cell culture) and clinical (blood, urine, cerebrospinal fluid, microdialyates, tissue) studies. We will also discuss the rewards, challenges, and future directions for the application of proteomics technology to the study of various disease phenotypes. To capture the dynamic range of cerebrovascular injury and repair with a translational targeted and discovery approach, we emphasize the importance of complementing innovative proteomic technology with existing molecular biology models in preclinical studies, and the need to advance pharmacoproteomics to directly probe clinical physiology and gauge therapeutic efficacy at the bedside." @default.
- W1577173685 created "2016-06-24" @default.
- W1577173685 creator A5011885000 @default.
- W1577173685 creator A5020104307 @default.
- W1577173685 creator A5022326470 @default.
- W1577173685 creator A5034622744 @default.
- W1577173685 creator A5091447153 @default.
- W1577173685 date "2012-12-01" @default.
- W1577173685 modified "2023-10-14" @default.
- W1577173685 title "Application of proteomics to cerebrovascular disease" @default.
- W1577173685 cites W1502081846 @default.
- W1577173685 cites W1521296165 @default.
- W1577173685 cites W1835677840 @default.
- W1577173685 cites W1928670726 @default.
- W1577173685 cites W1955736456 @default.
- W1577173685 cites W1966610668 @default.
- W1577173685 cites W1966765184 @default.
- W1577173685 cites W1971848426 @default.
- W1577173685 cites W1972177343 @default.
- W1577173685 cites W1972395654 @default.
- W1577173685 cites W1972408586 @default.
- W1577173685 cites W1976239388 @default.
- W1577173685 cites W1977184198 @default.
- W1577173685 cites W1979664027 @default.
- W1577173685 cites W1981870052 @default.
- W1577173685 cites W1982935098 @default.
- W1577173685 cites W1984469974 @default.
- W1577173685 cites W1987096764 @default.
- W1577173685 cites W1987197699 @default.
- W1577173685 cites W1987774571 @default.
- W1577173685 cites W1988805890 @default.
- W1577173685 cites W1989376534 @default.
- W1577173685 cites W1989903772 @default.
- W1577173685 cites W1990711278 @default.
- W1577173685 cites W1992359809 @default.
- W1577173685 cites W1992758695 @default.
- W1577173685 cites W1994426685 @default.
- W1577173685 cites W1996813353 @default.
- W1577173685 cites W1997028817 @default.
- W1577173685 cites W1997974476 @default.
- W1577173685 cites W1998475570 @default.
- W1577173685 cites W1998802283 @default.
- W1577173685 cites W1999369934 @default.
- W1577173685 cites W2000027035 @default.
- W1577173685 cites W2001216494 @default.
- W1577173685 cites W2001560751 @default.
- W1577173685 cites W2004997757 @default.
- W1577173685 cites W2006869437 @default.
- W1577173685 cites W2007326944 @default.
- W1577173685 cites W2009065888 @default.
- W1577173685 cites W2010526081 @default.
- W1577173685 cites W2011875859 @default.
- W1577173685 cites W2011976336 @default.
- W1577173685 cites W2015732856 @default.
- W1577173685 cites W2023250693 @default.
- W1577173685 cites W2024276472 @default.
- W1577173685 cites W2026332221 @default.
- W1577173685 cites W2030519226 @default.
- W1577173685 cites W2031375851 @default.
- W1577173685 cites W2031441877 @default.
- W1577173685 cites W2036489895 @default.
- W1577173685 cites W2036616175 @default.
- W1577173685 cites W2036641811 @default.
- W1577173685 cites W2037807428 @default.
- W1577173685 cites W2041601471 @default.
- W1577173685 cites W2042379312 @default.
- W1577173685 cites W2043256631 @default.
- W1577173685 cites W2043444868 @default.
- W1577173685 cites W2045800415 @default.
- W1577173685 cites W2046616634 @default.
- W1577173685 cites W2046915310 @default.
- W1577173685 cites W2047951064 @default.
- W1577173685 cites W2048047884 @default.
- W1577173685 cites W2048790899 @default.
- W1577173685 cites W2051222259 @default.
- W1577173685 cites W2053999004 @default.
- W1577173685 cites W2054414674 @default.
- W1577173685 cites W205495280 @default.
- W1577173685 cites W2055604652 @default.
- W1577173685 cites W2056994600 @default.
- W1577173685 cites W2060481603 @default.
- W1577173685 cites W2061173173 @default.
- W1577173685 cites W2065345218 @default.
- W1577173685 cites W2065801226 @default.
- W1577173685 cites W2067132969 @default.
- W1577173685 cites W2069219223 @default.
- W1577173685 cites W2069508712 @default.
- W1577173685 cites W2070543132 @default.
- W1577173685 cites W2073384304 @default.
- W1577173685 cites W2074261197 @default.
- W1577173685 cites W2076273642 @default.
- W1577173685 cites W2077839585 @default.
- W1577173685 cites W2078361213 @default.
- W1577173685 cites W2078460298 @default.
- W1577173685 cites W2081974839 @default.
- W1577173685 cites W2083134798 @default.
- W1577173685 cites W2083942569 @default.
- W1577173685 cites W2084053186 @default.