Matches in SemOpenAlex for { <https://semopenalex.org/work/W157720121> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W157720121 endingPage "8" @default.
- W157720121 startingPage "523" @default.
- W157720121 abstract "Tumor growth inhibitory and radiosensitizing effects of the alcoholic root extract of P. rosea was studied on experimental mouse tumors, S-180 solid tumor and Ehrlich ascites carcinoma in vivo. Intraperitoneal injection of 50 mg/kg of Plumbago extract (PE) for 10 days starting from 24 hr after intradermal inoculation of S-180 cells in BALB/c mice produced about 16% complete response (CR). The CR% increased with increase in drug dose, to 50% at 100 mg/kg for 10 days. As 100 mg/kg produced toxic side effects, lower doses were used with other treatment modalities, radiation (RT) and hyperthermia (HT). Treatment of 50 mm3 tumor with PE (75 mg/kg) for 10 days with local RT (10 Gy) and/or HT (43 degrees C, 30 min) subadditively increased the CR% and tumor free survival. The combination also significantly reduced the growth rates of uncured tumors. The PE significantly reduced the tumor glutathione content and this effect was markedly enhanced by the combination of the three modalities. PE alone was not very effective in preventing the growth of Ehrlich ascites carcinoma in Swiss mice, though it increased mean survival time and ILS% of the mice. But with radiation it produced a synergistic effect in increasing the tumor inhibition and 120 day animal survival from 10% to 50%. The results demonstrate that though PE may have only a weak antitumor effect, it may be a good candidate for use with radiation to enhance the tumor killing effect." @default.
- W157720121 created "2016-06-24" @default.
- W157720121 creator A5044899100 @default.
- W157720121 creator A5059602360 @default.
- W157720121 creator A5076693480 @default.
- W157720121 date "1994-08-01" @default.
- W157720121 modified "2023-10-18" @default.
- W157720121 title "In vivo tumor inhibitory and radiosensitizing effects of an Indian medicinal plant, Plumbago rosea on experimental mouse tumors." @default.
- W157720121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7959931" @default.
- W157720121 hasPublicationYear "1994" @default.
- W157720121 type Work @default.
- W157720121 sameAs 157720121 @default.
- W157720121 citedByCount "27" @default.
- W157720121 countsByYear W1577201212013 @default.
- W157720121 countsByYear W1577201212014 @default.
- W157720121 countsByYear W1577201212016 @default.
- W157720121 countsByYear W1577201212017 @default.
- W157720121 countsByYear W1577201212022 @default.
- W157720121 crossrefType "journal-article" @default.
- W157720121 hasAuthorship W157720121A5044899100 @default.
- W157720121 hasAuthorship W157720121A5059602360 @default.
- W157720121 hasAuthorship W157720121A5076693480 @default.
- W157720121 hasConcept C126322002 @default.
- W157720121 hasConcept C150903083 @default.
- W157720121 hasConcept C181199279 @default.
- W157720121 hasConcept C185592680 @default.
- W157720121 hasConcept C207001950 @default.
- W157720121 hasConcept C2776197502 @default.
- W157720121 hasConcept C2780159080 @default.
- W157720121 hasConcept C2780496750 @default.
- W157720121 hasConcept C502942594 @default.
- W157720121 hasConcept C538909803 @default.
- W157720121 hasConcept C55493867 @default.
- W157720121 hasConcept C71924100 @default.
- W157720121 hasConcept C86803240 @default.
- W157720121 hasConcept C98274493 @default.
- W157720121 hasConceptScore W157720121C126322002 @default.
- W157720121 hasConceptScore W157720121C150903083 @default.
- W157720121 hasConceptScore W157720121C181199279 @default.
- W157720121 hasConceptScore W157720121C185592680 @default.
- W157720121 hasConceptScore W157720121C207001950 @default.
- W157720121 hasConceptScore W157720121C2776197502 @default.
- W157720121 hasConceptScore W157720121C2780159080 @default.
- W157720121 hasConceptScore W157720121C2780496750 @default.
- W157720121 hasConceptScore W157720121C502942594 @default.
- W157720121 hasConceptScore W157720121C538909803 @default.
- W157720121 hasConceptScore W157720121C55493867 @default.
- W157720121 hasConceptScore W157720121C71924100 @default.
- W157720121 hasConceptScore W157720121C86803240 @default.
- W157720121 hasConceptScore W157720121C98274493 @default.
- W157720121 hasIssue "8" @default.
- W157720121 hasLocation W1577201211 @default.
- W157720121 hasOpenAccess W157720121 @default.
- W157720121 hasPrimaryLocation W1577201211 @default.
- W157720121 hasRelatedWork W157720121 @default.
- W157720121 hasRelatedWork W1988017207 @default.
- W157720121 hasRelatedWork W2005558852 @default.
- W157720121 hasRelatedWork W2052185098 @default.
- W157720121 hasRelatedWork W2054741548 @default.
- W157720121 hasRelatedWork W2068003021 @default.
- W157720121 hasRelatedWork W2114534540 @default.
- W157720121 hasRelatedWork W2415244988 @default.
- W157720121 hasRelatedWork W2416948774 @default.
- W157720121 hasRelatedWork W2899084033 @default.
- W157720121 hasVolume "32" @default.
- W157720121 isParatext "false" @default.
- W157720121 isRetracted "false" @default.
- W157720121 magId "157720121" @default.
- W157720121 workType "article" @default.