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- W1577481766 abstract "Twelve cases of uveal melanoma (T3N₀M₀:11 patients, T4N₀M₀:1 patient) treated with Gamma Knife stereotactic radiosurgery are reported. Our protocol includes preoperative ocular and systemic assessments with complete ocular examination, ophthalmoscopy, fundus photography, fluorangiography, standardized echography, CT and MRI, chest X-rays, liver echography and blood tests. The follow-up program is mainly based on echographic evaluation of tumor thickness and size. The procedures include fixation of the eye, application of the stereotactic Leksell frame G, CT/MRI localization of the melanoma, dose planning and treatment with the Gamma Knife (B type). A mean surface dose of 55 ± 10 Gy was administered at the 60–90% isodose curve using 4- to 14-mm collimators and a number of shots ranging from 1 to 6. A significant reduction (10–41 %) in echographic thickness of the tumor was shown in 6 cases with a follow-up of 3–12 months. In 4 patients, the tumor size was still unchanged after 1–10 months. The single high-dose radiation delivered to the target and the high spatial accuracy are the main advantages of stereotactic radiosurgery for the treatment of posterior uveal melanomas. A longer follow-up is needed to further validate this new application of Gamma Knife radiosurgery." @default.
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- W1577481766 date "1995-01-01" @default.
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- W1577481766 title "Stereotactic Radiosurgery of Uveal Melanomas: Preliminary Results with Gamma Knife Treatment" @default.
- W1577481766 doi "https://doi.org/10.1159/000098766" @default.
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